The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7 (Q34124022)

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8 January 2020

title

The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7 (English)

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8 January 2020

main subject

human papilloma virus

1 reference

human papillomavirus

29 September 2024

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8 January 2020

Hillary V Allen

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8 January 2020

Megan N Thobe

1 reference

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8 January 2020

Elizabeth E Jones

1 reference

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8 January 2020

Kristen B Habash

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8 January 2020

Karl Münger

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8 January 2020

Susanne I Wells

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8 January 2020

language of work or name

English

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publication date

1 November 2005

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8 January 2020

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8 January 2020

volume

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8 January 2020

issue

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8 January 2020

page(s)

14309-14317

1 reference

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The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin

8 January 2020

cites work

1 reference

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Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK

5 July 2018

1 reference

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Functional domains of the ubiquitous chromatin protein DEK.

5 July 2018

1 reference

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Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7.

5 July 2018

1 reference

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Structure-specific binding of the proto-oncogene protein DEK to DNA.

5 July 2018

1 reference

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Minireview: DEK and gene regulation, oncogenesis and AIDS.

5 July 2018

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Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells

5 July 2018

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RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells

5 July 2018

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Transcriptional activation by AP-2alpha is modulated by the oncogene DEK

5 July 2018

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Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes

5 July 2018

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Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek

5 July 2018

1 reference

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Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA.

5 July 2018

1 reference

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Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis

5 July 2018

1 reference

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The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils

5 July 2018

1 reference

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Persistent human papillomavirus infection and cervical neoplasia

5 July 2018

1 reference

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Subcellular localization of the human proto-oncogene protein DEK

5 July 2018

1 reference

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Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

5 July 2018

1 reference

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Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs

5 July 2018

1 reference

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Rapid induction of senescence in human cervical carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes

5 July 2018

1 reference

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The identification of novel therapeutic targets for the treatment of malignant brain tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Cancer, aging and cellular senescence

5 July 2018

1 reference

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SAP - a putative DNA-binding motif involved in chromosomal organization

5 July 2018

1 reference

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Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.

5 July 2018

1 reference

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Papillomavirus E2 induces p53-independent apoptosis in HeLa cells

5 July 2018

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Control of apoptosis and mitotic spindle checkpoint by survivin

5 July 2018

1 reference

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Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis

5 July 2018

1 reference

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A simplified system for generating recombinant adenoviruses

5 July 2018

1 reference

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Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes

5 July 2018

1 reference

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DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer

5 July 2018

1 reference

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Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

5 July 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

5 July 2018

1 reference

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Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Functional analysis of E2-mediated repression of the HPV18 P105 promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.

28 October 2018

1 reference

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280217

Autoantibodies to DEK oncoprotein in systemic lupus erythematosus (SLE)

28 October 2018

1 reference

12 December 2020

YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter

1 reference

12 December 2020

The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours

1 reference

12 December 2020

The putative oncoprotein DEK, part of a chimera protein associated with acute myeloid leukaemia, is an autoantigen in juvenile rheumatoid arthritis

1 reference

12 December 2020

Identification and characterization of genes associated with human hepatocellular carcinogenesis

1 reference

12 December 2020

Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres

1 reference

12 December 2020

1 reference

12 December 2020

Autoantibodies to DEK oncoprotein in human inflammatory disease

1 reference

12 December 2020

10.1128/JVI.79.22.14309-14317.2005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16254365%20AND%20SRC:MED&resulttype=core&format=json

release_b6obfyentrgubf6wr7bq2piueu

8 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/b6obfyentrgubf6wr7bq2piueu

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16254365%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

16254365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16254365%20AND%20SRC:MED&resulttype=core&format=json