Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR. (Q34117694)

31 July 2017

title

Krüppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR. (English)

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31 July 2017

Suman Govindaraju

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31 July 2017

Beth S Lee

series ordinal

1 reference

31 July 2017

publication date

8 August 2014

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Cellular Physiology and Biochemistry

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

519-532

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Adaptive and maladaptive expression of the mRNA regulatory protein HuR

31 July 2017

cites work

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The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition

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Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

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HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop

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Kruppel-like factor-15 inhibits the proliferation of mesangial cells

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Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation

5 July 2018

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The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation

5 July 2018

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Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo

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RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

5 July 2018

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Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites

5 July 2018

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Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability

5 July 2018

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RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.

5 July 2018

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5 July 2018

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Up-regulation of Krüppel-Like Factor 8 Promotes Tumor Invasion and Indicates Poor Prognosis for Hepatocellular Carcinoma

5 July 2018

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Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma

5 July 2018

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Role of the RNA-binding protein HuR in human renal cell carcinoma

5 July 2018

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Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo

5 July 2018

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Transcriptional control of human antigen R by bone morphogenetic protein

5 July 2018

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5 July 2018

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Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.

5 July 2018

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MicroRNA-125a represses cell growth by targeting HuR in breast cancer

5 July 2018

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Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney

5 July 2018

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Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

5 July 2018

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Ubiquitin-mediated proteolysis of HuR by heat shock

5 July 2018

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The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development

5 July 2018

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miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

5 July 2018

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NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.

5 July 2018

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Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

5 July 2018

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Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells

5 July 2018

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5 July 2018

1 reference

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Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha

5 July 2018

1 reference

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Posttranscriptional orchestration of an anti-apoptotic program by HuR.

5 July 2018

1 reference

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HuR: post-transcriptional paths to malignancy.

5 July 2018

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Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2.

5 July 2018

1 reference

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Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells

5 July 2018

1 reference

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Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter

5 July 2018

1 reference

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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes

5 July 2018

1 reference

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Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

HuR stabilizes vacuolar H+-translocating ATPase mRNA during cellular energy depletion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

5 July 2018

1 reference

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Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

5 July 2018

1 reference

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Role of the RNA-binding protein HuR in colon carcinogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression

5 July 2018

1 reference

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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

5 July 2018

1 reference

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5 July 2018

1 reference

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Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor

5 July 2018

1 reference

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Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription

5 July 2018

1 reference

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The ER-overload response: activation of NF-kappa B.

5 July 2018

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Sp1 is a critical regulator of the Wilms' tumor-1 gene

5 July 2018

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A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

5 July 2018

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Kruppel-like factor 15 modulates renal interstitial fibrosis by ERK/MAPK and JNK/MAPK pathways regulation

5 July 2018

1 reference

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Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Competitive PCR for precise nucleic acid quantification.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Induction of Zf9 in the kidney following early ischemia/reperfusion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4151249

Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25116351

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1159/000363019

1 reference

31 July 2017

1 reference

31 July 2017

1 reference