Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy (Q34026081)

30 July 2017

title

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy (English)

1 reference

30 July 2017

Carrie Sougnez

0 references

Kristian Cibulskis

Kristian Cibulskis

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Gad Getz

Gad Getz

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Wendy Winckler

Wendy Winckler

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Heidi Greulich

Heidi Greulich

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Eric Lander

Eric S Lander

1 reference

30 July 2017

Harold E Varmus

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30 July 2017

Chris Sander

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30 July 2017

Marc Ladanyi

1 reference

30 July 2017

Boris Reva

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Alex Lash

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Sven Nelander

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Samuel Singer

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Robert G Maki

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Jordi Barretina Ginesta

Jordi Barretina

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Craig H Mermel

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Matthew Meyerson

1 reference

30 July 2017

Levi A Garraway

1 reference

30 July 2017

David E Root

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30 July 2017

Barbara A Weir

1 reference

30 July 2017

Rameen Beroukhim

1 reference

30 July 2017

Tsuyoshi Saito

1 reference

30 July 2017

Barry S Taylor

1 reference

30 July 2017

Shantanu Banerji

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30 July 2017

Alexis H Ramos

1 reference

30 July 2017

Mariana Lagos-Quintana

1 reference

30 July 2017

Penelope L Decarolis

1 reference

30 July 2017

Kinjal Shah

1 reference

30 July 2017

Nicholas D Socci

1 reference

30 July 2017

Alan Ho

1 reference

30 July 2017

Derek Y Chiang

1 reference

30 July 2017

Yevgenyi Antipin

1 reference

30 July 2017

John E Major

1 reference

30 July 2017

Charles Hatton

1 reference

30 July 2017

Richard Nicoletti

1 reference

30 July 2017

Megan Hanna

1 reference

30 July 2017

Ted Sharpe

1 reference

30 July 2017

Tim J Fennell

1 reference

30 July 2017

Robert C Onofrio

1 reference

30 July 2017

Neerav Shukla

1 reference

30 July 2017

Christopher Lau

1 reference

30 July 2017

Serena J Silver

1 reference

30 July 2017

Agnes Viale

1 reference

30 July 2017

William R Sellers

1 reference

30 July 2017

Gary K Schwartz

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30 July 2017

Cristina R Antonescu

1 reference

30 July 2017

language of work or name

English

0 references

publication date

4 July 2010

1 reference

30 July 2017

1 reference

30 July 2017

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30 July 2017

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30 July 2017

page(s)

715-721

1 reference

A census of amplified and overexpressed human cancer genes

30 July 2017

cites work

1 reference

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5 July 2018

Cancer statistics, 2009

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

5 July 2018

1 reference

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Highly parallel identification of essential genes in cancer cells

5 July 2018

1 reference

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Somatic mutations affect key pathways in lung adenocarcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

PI3K pathway alterations in cancer: variations on a theme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Functional copy-number alterations in cancer

5 July 2018

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

5 July 2018

1 reference

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Drug-sensitive FGFR2 mutations in endometrial carcinoma

5 July 2018

1 reference

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Defining the blueprint of the cancer genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Genetics of soft tissue tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Patterns of somatic mutation in human cancer genomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Statistical practice in high-throughput screening data analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

SNPdetector: a software tool for sensitive and accurate SNP detection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Detection of large-scale variation in the human genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

High frequency of mutations of the PIK3CA gene in human cancers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

A census of human cancer genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

dChipSNP: significance curve and clustering of SNP-array-based loss-of-heterozygosity data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Establishment of a novel human dedifferentiated liposarcoma cell line, FU-DDLS-1: conventional and molecular cytogenetic characterization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

PDGFRA activating mutations in gastrointestinal stromal tumors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Consed: a graphical tool for sequence finishing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911503

Malignant peripheral nerve sheath tumors in neurofibromatosis 1.

5 July 2018

1 reference

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients

21 January 2018

1 reference

Comprehensive NF1 screening on cultured Schwann cells from neurofibromas

21 January 2018

1 reference

Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors.

21 January 2018

1 reference

Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.

21 January 2018

1 reference

A probability-based approach for the analysis of large-scale RNAi screens.

21 January 2018

1 reference

HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

21 January 2018

1 reference

CancerGenes: a gene selection resource for cancer genome projects

21 January 2018

1 reference

miRBase: tools for microRNA genomics

21 January 2018

1 reference

Genomic mutation consequence calculator

21 January 2018

1 reference

Determinants of protein function revealed by combinatorial entropy optimization

21 January 2018

1 reference

High-throughput oncogene mutation profiling in human cancer

21 January 2018

1 reference

Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20601955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20601955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NG.619

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference