Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding (Q33945585)

30 July 2017

title

Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding (English)

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30 July 2017

Vilhelm A Bohr

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30 July 2017

Marie L Rossi

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30 July 2017

Avik K Ghosh

series ordinal

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30 July 2017

Tomasz Kulikowicz

series ordinal

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30 July 2017

Deborah L Croteau

series ordinal

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30 July 2017

publication date

6 May 2010

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30 July 2017

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

796-804

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describes a project that uses

30 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2893255/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Drosophila RecQ4 has a 3'-5' DNA helicase activity that is essential for viability

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dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila

5 July 2018

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Direct and indirect roles of RECQL4 in modulating base excision repair capacity

5 July 2018

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DNA helicase activity in purified human RECQL4 protein

5 July 2018

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Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4

5 July 2018

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Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging

5 July 2018

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RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA)

5 July 2018

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Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents

5 July 2018

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Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases

5 July 2018

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Acetylation regulates WRN catalytic activities and affects base excision DNA repair

5 July 2018

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Multiple cutaneous neoplasms in a patient with Rothmund-Thomson syndrome: case report and published work review

5 July 2018

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RecQ helicases: guardian angels of the DNA replication fork

5 July 2018

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Human premature aging, DNA repair and RecQ helicases

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Molecular genetics of RecQ helicase disorders

5 July 2018

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The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress

5 July 2018

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Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork

5 July 2018

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Mechanisms by which Bloom protein can disrupt recombination intermediates of Okazaki fragment maturation

5 July 2018

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The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Two primary osteosarcomas in a patient with Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

The Bloom's syndrome gene product promotes branch migration of holliday junctions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Functional and physical interaction between WRN helicase and human replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Replication protein A induces the unwinding of long double-stranded DNA regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

DNA unwinding by replication protein A is a property of the 70 kDa subunit and is facilitated by phosphorylation of the 32 kDa subunit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Processing of recombination intermediates by the RecG and RuvAB proteins of Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Recombinant replication protein A: expression, complex formation, and functional characterization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Instability of lymphocyte chromosomes in a girl with Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Clonal lines of aneuploid cells in Rothmund-Thomson syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Rothmund-Thomson syndrome: review of the world literature

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

DNA unwinding activity of replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893255

[Rothmund-Thomson syndrome, trisomy 8 mosaicism and RECQ4 gene mutation]

29 October 2018

1 reference

12 December 2020

An unusual mutation in RECQ4 gene leading to Rothmund–Thomson syndrome

1 reference

12 December 2020

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

1 reference

12 December 2020

Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts

1 reference

12 December 2020

Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome

1 reference

12 December 2020

Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion

1 reference

12 December 2020

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

12 December 2020

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

12 December 2020

10.1016/J.DNAREP.2010.04.003

Identifiers

DOI

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30 July 2017

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30 July 2017

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