The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones. (Q33633104)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones (English)

1 reference

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1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Carmel Cluning

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Bryan K Ward

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Ajanthy Arulpragasam

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Thomas Ratajczak

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

publication date

17 May 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

published in

Molecular Endocrinology

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1 March 2020

volume

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1 March 2020

issue

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1 March 2020

page(s)

1020-1035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

FKBP51 and FKBP52 in signaling and disease

1 March 2020

cites work

1 reference

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FKBP51-a selective modulator of glucocorticoid and androgen sensitivity

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Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis

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The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

21 June 2018

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The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.

21 June 2018

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The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

21 June 2018

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Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity.

21 June 2018

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21 June 2018

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Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling

21 June 2018

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A surface on the androgen receptor that allosterically regulates coactivator binding

21 June 2018

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Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

21 June 2018

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Glucocorticoids, metabolism and metabolic diseases.

21 June 2018

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A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

21 June 2018

1 reference

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Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology

21 June 2018

1 reference

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Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain

21 June 2018

1 reference

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The Hsp90 cochaperone p23 is essential for perinatal survival.

21 June 2018

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FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform

21 June 2018

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Chaperoning steroid hormone action

21 June 2018

1 reference

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Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

21 June 2018

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Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation

21 June 2018

1 reference

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Stress and the brain: from adaptation to disease

21 June 2018

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Physiological role for the cochaperone FKBP52 in androgen receptor signaling

21 June 2018

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Functional specificity of co-chaperone interactions with Hsp90 client proteins.

21 June 2018

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Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.

21 June 2018

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FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.

21 June 2018

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Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids

21 June 2018

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Cortisol resistance in the New World revisited

21 June 2018

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The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

21 June 2018

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3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex

21 June 2018

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Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement

21 June 2018

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Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors

21 June 2018

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The Hsp90 Cochaperone p23 Is the Limiting Component of the Multiprotein Hsp90/Hsp70-based Chaperone System in Vivo Where It Acts to Stabilize the Client Protein·Hsp90 Complex

21 June 2018

1 reference

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Immunophilin chaperones in steroid receptor signalling

21 June 2018

1 reference

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

21 June 2018

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The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

21 June 2018

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The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

21 June 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 June 2018

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Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

21 June 2018

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Familial/sporadic glucocorticoid resistance syndrome and hypertension

21 June 2018

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Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

21 June 2018

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A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins

21 June 2018

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Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces

21 June 2018

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Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding

21 June 2018

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Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

21 June 2018

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The coregulator exchange in transcriptional functions of nuclear receptors

21 June 2018

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Structural determinants of aldosterone binding selectivity in the mineralocorticoid receptor

21 June 2018

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Stable proline box motif at the N-terminal end of alpha-helices

21 June 2018

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Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways

21 June 2018

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Atomic structure of progesterone complexed with its receptor

21 June 2018

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DNA binding of the glucocorticoid receptor is not essential for survival

21 June 2018

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Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70.

21 June 2018

1 reference

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Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin

21 June 2018

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Ribosomal protein L32 of Saccharomyces cerevisiae influences both the splicing of its own transcript and the processing of rRNA.

21 June 2018

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Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

21 June 2018

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Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids

21 June 2018

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Anomalies in the endocrine axes of the guinea pig: relevance to human physiology and disease

21 June 2018

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Hypercortisolism and obesity

21 June 2018

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Steroid hormone receptors: many actors in search of a plot

21 June 2018

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The nuclear receptor superfamily: the second decade

21 June 2018

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Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene

21 June 2018

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The steroid binding domain influences intracellular solubility of the baculovirus overexpressed glucocorticoid and mineralocorticoid receptors

21 June 2018

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Isolation of Hsp90 mutants by screening for decreased steroid receptor function

21 June 2018

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Cortisol resistance and the guinea pig glucocorticoid receptor.

21 June 2018

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Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

21 June 2018

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LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones

21 June 2018

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Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

21 June 2018

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Glucocorticoid hormone resistance during primate evolution: receptor-mediated mechanisms

21 June 2018

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Adrenocortical steroids and the brain

21 June 2018

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The steroid and thyroid hormone receptor superfamily

21 June 2018

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Mammalian glucocorticoid receptor derivatives enhance transcription in yeast

21 June 2018

1 reference

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Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Reduced levels of hsp90 compromise steroid receptor action in vivo

21 June 2018

1 reference

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Localization of the 90-kDa heat shock protein-binding site within the hormone-binding domain of the glucocorticoid receptor by peptide competition

21 June 2018

1 reference

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The steroid receptor superfamily: mechanisms of diversity

21 June 2018

1 reference

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Genetic dissection of the signaling domain of a mammalian steroid receptor in yeast

21 June 2018

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Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity

21 June 2018

1 reference

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Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

30 October 2018

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The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Structural determinants of cortisol resistance in the guinea pig glucocorticoid receptor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59).

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Dual roles of 90-kDa heat shock protein in the function of the mineralocorticoid receptor.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

Unique sequences in the guinea pig glucocorticoid receptor induce constitutive transactivation and decrease steroid sensitivity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5415241

A canonical structure for the ligand-binding domain of nuclear receptors

10 December 2018

1 reference

12 December 2020

Hsp90: from structure to phenotype

1 reference

12 December 2020

Selective Interaction of hsp90 with an Estrogen Receptor Ligand-binding Domain Containing a Point Mutation

1 reference

12 December 2020

Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes

1 reference

12 December 2020

Anomalies in the Endocrine Axes of the Guinea Pig: Relevance to Human Physiology and Disease*

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2012-1023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

23686112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23686112%20AND%20SRC:MED&resulttype=core&format=json