EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors (Q33273472)

25 July 2017

title

EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors (English)

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25 July 2017

Yoh Dobashi

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25 July 2017

Shioto Suzuki

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25 July 2017

Eiichi Sato

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25 July 2017

Yoshiki Hamada

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25 July 2017

Takashi Yanagawa

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25 July 2017

Akishi Ooi

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25 July 2017

publication date

31 July 2009

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25 July 2017

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25 July 2017

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25 July 2017

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25 July 2017

page(s)

1328-1340

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The biology behind mTOR inhibition in sarcoma

25 July 2017

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Involvement of epidermal growth factor receptor and downstream molecules in bone and soft tissue tumors

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mTOR, translation initiation and cancer

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AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling.

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

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Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells

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Phosphoprotein pathway mapping: Akt/mammalian target of rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival

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CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling

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Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas

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Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma

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Effectiveness of cetuximab/gefitinib in the therapy of a sacral chordoma

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Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

21 January 2018

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Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

21 January 2018

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Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

21 January 2018

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Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

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Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

21 January 2018

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Regulation of ribosomal protein S6 kinases by ubiquitination.

21 January 2018

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Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

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mTOR signaling contributes to chondrocyte differentiation

21 January 2018

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Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells

21 January 2018

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regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis

21 January 2018

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Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

21 January 2018

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Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma

21 January 2018

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Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FMODPATHOL.2009.104

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/MODPATHOL.2009.104

1 reference

Dimensions Publication ID

25 July 2017

1017010059

0 references

1 reference