The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton (Q30501999)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21551065%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton (English)

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31 January 2020

0 references

0 references

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31 January 2020

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31 January 2020

Sebastian Kicka

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31 January 2020

Zhouxin Shen

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31 January 2020

Susan Lee

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31 January 2020

Steven Briggs

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31 January 2020

Richard A Firtel

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31 January 2020

publication date

5 May 2011

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Molecular Biology of the Cell

31 January 2020

published in

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31 January 2020

volume

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31 January 2020

issue

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31 January 2020

page(s)

2198-2211

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A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

31 January 2020

cites work

1 reference

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The exocytic gene secA is required for Dictyostelium cell motility and osmoregulation

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A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration

20 June 2018

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GTPase activity plays a key role in the pathobiology of LRRK2.

20 June 2018

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Characterization of the Roco protein family in Dictyostelium discoideum

20 June 2018

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20 June 2018

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Filamins regulate cell spreading and initiation of cell migration

20 June 2018

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

20 June 2018

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20 June 2018

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Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

20 June 2018

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Spatiotemporal regulation of Ras activity provides directional sensing

20 June 2018

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Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

20 June 2018

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Regulation of contractile vacuole formation and activity in Dictyostelium

20 June 2018

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Directional sensing during chemotaxis

20 June 2018

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LRRK2 regulates synaptic vesicle endocytosis

20 June 2018

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

20 June 2018

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Actin binding domains direct actin-binding proteins to different cytoskeletal locations

20 June 2018

1 reference

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Chemotaxis: navigating by multiple signaling pathways

20 June 2018

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G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

20 June 2018

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Cell motility and cytoskeletal regulation in invasion and metastasis

20 June 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

20 June 2018

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Rab1 defines a novel pathway connecting the pre-Golgi intermediate compartment with the cell periphery

20 June 2018

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

20 June 2018

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

20 June 2018

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Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

20 June 2018

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Chemotaxis: signalling the way forward

20 June 2018

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Roc, a Ras/GTPase domain in complex proteins

20 June 2018

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Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis

20 June 2018

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Rapid generation of gene disruption constructs by in vitro transposition and identification of a Dictyostelium protein kinase that regulates its rate of growth and development

20 June 2018

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COPI recruitment is modulated by a Rab1b-dependent mechanism

20 June 2018

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Cellular motility driven by assembly and disassembly of actin filaments

20 June 2018

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The identification of pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum

20 June 2018

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A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium

20 June 2018

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Identification of four candidate cGMP targets in Dictyostelium

20 June 2018

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Filamins as integrators of cell mechanics and signalling

20 June 2018

1 reference

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Myosin II-independent cytokinesis in Dictyostelium: its mechanism and implications

20 June 2018

1 reference

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Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

20 June 2018

1 reference

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Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128523

Differential inhibition of multiple vesicular transport steps between the endoplasmic reticulum and trans Golgi network

20 June 2018

1 reference

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Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport

20 June 2018

1 reference

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Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods

20 June 2018

1 reference

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Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination.

20 June 2018

1 reference

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Targeted disruption of the ABP-120 gene leads to cells with altered motility

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3128523

The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum

20 June 2018

1 reference

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Understanding eukaryotic chemotaxis: a pseudopod-centred view

26 November 2018

1 reference

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Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.

26 November 2018

1 reference

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Ancient origin of the Parkinson disease gene LRRK2.

26 November 2018

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Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium.

26 November 2018

1 reference

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RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium.

26 November 2018

1 reference

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A novel partner for Dictyostelium filamin is an alpha-helical developmentally regulated protein.

26 November 2018

1 reference

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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

26 November 2018

1 reference

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A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells.

26 November 2018

1 reference

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The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium

26 November 2018

1 reference

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Possible roles of the endocytic cycle in cell motility

26 November 2018

1 reference

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Recruitment of a myosin heavy chain kinase to actin-rich protrusions in Dictyostelium

26 November 2018

1 reference

12 December 2020

Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells

1 reference

12 December 2020

Mechanisms of amoeboid chemotaxis: an evaluation of the cortical expansion model

1 reference

12 December 2020

LRRK2 mutations and Parkinsonism

1 reference

12 December 2020

Analysis of signal transduction: formation of cAMP, cGMP, and Ins(1,4,5)P3 in vivo and in vitro

1 reference

12 December 2020

A phototaxis signalling complex in Dictyostelium discoideum

1 reference

12 December 2020

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E10-12-0937

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21551065%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21551065%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

21551065

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21551065%20AND%20SRC:MED&resulttype=core&format=json