Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides (Q30438086)

19 August 2017

1 reference

title

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides (English)

1 reference

19 August 2017

Peter Wipf

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19 August 2017

Chad D Hopkins

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19 August 2017

11 March 2009

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19 August 2017

Natural Product Reports

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

19 August 2017

585-601

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Microtubule binding and disruption and induction of premature senescence by disorazole C(1).

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Microtubule-stabilizing natural products as promising cancer therapeutics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

New therapeutic options for chemotherapy-resistant metastatic breast cancer: the epothilones.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Discovery and development of the epothilones : a novel class of antineoplastic drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Review: tubulin function, action of antitubulin drugs, and new drug development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Marine natural products and related compounds in clinical and advanced preclinical trials

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Chemistry and biology of curacin A.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Synthesis of enantioenriched propargylic alcohols related to polyketide natural products. A comparison of methodologies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Highly enantioselective phenylacetylene additions to both aliphatic and aromatic aldehydes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Relationship between chemotherapy response of small cell lung cancer and P-glycoprotein or multidrug resistance-related protein expression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Epothilones: a novel class of non-taxane microtubule-stabilizing agents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Multidrug resistance in cancer: role of ATP-dependent transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Myxobacteria, producers of novel bioactive substances

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

P-glycoprotein as a drug target in the treatment of multidrug resistant cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Novel mechanisms of drug resistance in leukemia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Gephyronic acid, a novel inhibitor of eukaryotic protein synthesis from Archangium gephyra (myxobacteria). Production, isolation, physico-chemical and biological properties, and mechanism of action

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Promotion of microtubule assembly in vitro by taxol

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Antibiotics from gliding bacteria. No.61. Gephyronic Acid, a Novel Inhibitor of Eukaryotic Protein Synthesis from Archangium gephyra (Myxobacteria). Production, Isolation, Physico-chemical and Biological Properties, and Mechanism of Action

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1039%2FB813799B

Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Methanolysis products of disorazole A1.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Total Synthesis as a Resource in the Discovery of Potentially Valuable Antitumor Agents: Cycloproparadicicol

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Chondramides A approximately D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (myxobacteria). Production, physico-chemical and biological properties.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2711774

Total synthesis of (-)-disorazole C1

26 November 2018

1 reference

12 December 2020

Design, synthesis, and biological properties of highly potent epothilone B analogues

1 reference

12 December 2020

Studies Directed toward the Synthesis of Ulapualide A. Asymmetric Synthesis of the C8-C25 Tris-Oxazole Fragment

1 reference

12 December 2020

Configurational assignment of rhizopodin, an actin-binding macrolide from the myxobacterium Myxococcus stipitatus

1 reference

12 December 2020

Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties

1 reference

12 December 2020

Studies on the total synthesis of disorazole C1. An advanced macrocycle intermediate

1 reference

12 December 2020

Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties

1 reference

12 December 2020

Toward the total synthesis of disorazole A(1) and C(1): asymmetric synthesis of a masked southern segment

1 reference

12 December 2020

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

1 reference

12 December 2020

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

1 reference

12 December 2020

Disorazol A, an efficient inhibitor of eukaryotic organisms isolated from myxobacteria

1 reference

12 December 2020

Antibiotics from Gliding Bacteria, LIX. Disorazoles, Highly Cytotoxic Metabolites from the Sorangicin-Producing BacteriumSorangium Cellulosum, Strain So ce12

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.1002/JLAC.199419940802

The Crocacins, Novel Antifungal and Cytotoxic Antibiotics fromChondromyces crocatus andChondromyces pediculatus (Myxobacteria): Isolation and Structure Elucidation

9 March 2024

0 references

Apicularen A and B, Cytotoxic 10-Membered Lactones with a Novel Mechanism of Action fromChondromyces Species (Myxobacteria): Isolation, Structure Elucidation, and Biosynthesis

0 references

Identifiers

DOI

10.1039/B813799B

1 reference

19 August 2017

1 reference

PMC publication ID

2711774

19 August 2017

PubMed publication ID

19387496

1 reference

PMC publication ID

2711774