Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function (Q28822425)

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Laurent Fattet

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Chen-Ting Ma

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Jinsong Qiu

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Patricia A Jennings

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Xiang-Dong Fu

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Joseph A Adams

describes a project that uses

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language of work or name

English

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publication date

1 March 2015

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published in

Biochemical Journal

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volume

466

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issue

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page(s)

311-22

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5053020/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Transportin-SR2 mediates nuclear import of phosphorylated SR proteins

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A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins

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The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

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The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing

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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

16 March 2017

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Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

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N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation

3 June 2018

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3 June 2018

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3 June 2018

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Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20.

3 June 2018

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3 June 2018

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The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation

3 June 2018

1 reference

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The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A

3 June 2018

1 reference

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Initial splice-site recognition and pairing during pre-mRNA splicing

3 June 2018

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Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

3 June 2018

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Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro.

3 June 2018

1 reference

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General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection

3 June 2018

1 reference

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Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

3 June 2018

1 reference

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Conditional knockout mice to study alternative splicing in vivo.

3 June 2018

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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20141373

Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.

21 January 2018

1 reference

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Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

21 January 2018

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Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing

21 January 2018

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Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

21 January 2018

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