Two-site interaction of nuclear factor of activated T cells with activated calcineurin (Q28616392)

3 February 2017

title

Two-site interaction of nuclear factor of activated T cells with activated calcineurin (English)

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3 February 2017

F. J. Garcia-Cozar

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3 February 2017

H. Okamura

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3 February 2017

J. F. Aramburu

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3 February 2017

K. T. Shaw

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3 February 2017

L. Pelletier

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3 February 2017

R. Showalter

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3 February 2017

E. Villafranca

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3 February 2017

A. Rao

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3 February 2017

language of work or name

English

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publication date

11 September 1998

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Journal of Biological Chemistry

3 February 2017

published in

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3 February 2017

volume

273

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3 February 2017

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3 February 2017

page(s)

23877–23883

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Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

3 February 2017

cites work

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NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

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Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

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Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes

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Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

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Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

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The transcription factor NF-ATc is essential for cardiac valve formation

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Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

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Mechanisms of transactivation by nuclear factor of activated T cells-1.

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Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import

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Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.

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T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1.

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Nuclear factor of activated T cells contains Fos and Jun.

21 January 2018

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The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

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21 January 2018

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Activation of calcineurin by limited proteolysis

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

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21 January 2018

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One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs

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Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.

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An Ion Pair in Class II Major Histocompatibility Complex Heterodimers Critical for Surface Expression and Peptide Presentation

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.37.23877

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