A PHD finger motif in the C terminus of RAG2 modulates recombination activity (Q28592944)

31 January 2017

title

A PHD finger motif in the C terminus of RAG2 modulates recombination activity (English)

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Recombination activating gene 2

31 January 2017

main subject

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GOA release 2020-03-11

Mark Ewalt

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Or P. Gozani

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Sheryl K. Elkin

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31 January 2017

Dmitri Ivanov

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31 January 2017

Colin G. Ferguson

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31 January 2017

Sven G. Hyberts

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31 January 2017

Zhen-Yu J. Sun

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31 January 2017

Glenn D. Prestwich

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31 January 2017

Junying Yuan

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31 January 2017

Gerhard Wagner

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31 January 2017

Marjorie A. Oettinger

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31 January 2017

Or P. Gozani

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31 January 2017

language of work or name

English

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publication date

5 August 2005

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

280

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31 January 2017

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31 January 2017

page(s)

28701–28710

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The V(D)J recombination activating gene, RAG-1.

31 January 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

21 January 2018

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V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

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Unraveling V(D)J recombination; insights into gene regulation

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Immunological disorders and DNA repair

21 January 2018

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Definition of a core region of RAG-2 that is functional in V(D)J recombination

21 January 2018

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Analysis of regions of RAG-2 important for V(D)J recombination

21 January 2018

1 reference

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

21 January 2018

1 reference

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The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

21 January 2018

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Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

21 January 2018

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The C-terminal portion of RAG2 protects against transposition in vitro

21 January 2018

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Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2

21 January 2018

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Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration

21 January 2018

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Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.

21 January 2018

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RAG mutations in human B cell-negative SCID.

21 January 2018

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Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

A short peptide at the C terminus is responsible for the nuclear localization of RAG2.

21 January 2018

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Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

21 January 2018

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Large-scale identification of mammalian proteins localized to nuclear sub-compartments

21 January 2018

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Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

21 January 2018

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The phosphatidylinositol 3-phosphate-binding FYVE finger

21 January 2018

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RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer

21 January 2018

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PHD domains and E3 ubiquitin ligases: viruses make the connection

21 January 2018

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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

21 January 2018

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Scores of RINGS but No PHDs in Ubiquitin Signaling

21 January 2018

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Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300.

21 January 2018

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ACF1 improves the effectiveness of nucleosome mobilization by ISWI through PHD-histone contacts.

21 January 2018

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IBIS--a tool for automated sequential assignment of protein spectra from triple resonance experiments

21 January 2018

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Torsion angle dynamics for NMR structure calculation with the new program DYANA

21 January 2018

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The Xplor-NIH NMR molecular structure determination package

21 January 2018

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

21 January 2018

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Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

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Unequal signal and coding joint formation in human V(D)J recombination

21 January 2018

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Mechanistic constraints on diversity in human V(D)J recombination

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Engineering a protein scaffold from a PHD finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Structural mechanism of endosome docking by the FYVE domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Ordered DNA release and target capture in RAG transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

The spreading influence of chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

21 January 2018

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Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

21 January 2018

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Curvature of clathrin-coated pits driven by epsin

21 January 2018

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Phosphoinositides: key players in cell signalling, in time and space.

21 January 2018

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Nuclear inositides: facts and perspectives

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

An expanded view of inositol signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

V(D)J recombination and RAG-mediated transposition in yeast.

21 January 2018

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Structural basis for vinculin activation at sites of cell adhesion.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504731200

A polybasic motif allows N-WASP to act as a sensor of PIP(2) density

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Phosphoinositide signaling; from affinity probes to pharmaceutical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Efficient Inhibition of Escherichia Coli RNA Polymerase by the Bacteriophage T4 AsiA Protein Requires that AsiA Binds First to Free σ70

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504731200

21 January 2018

Identifiers

DOI

10.1074/JBC.M504731200

1 reference

31 January 2017

1 reference