Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis (Q28587336)

31 January 2017

title

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis (English)

1 reference

apoptotic process involved in embryonic digit morphogenesis

31 January 2017

0 references

0 references

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902263

BCL2-associated X protein

1 reference

GOA release 2020-03-11

BCL2-antagonist/killer 1

1 reference

BCL2-like 11 (apoptosis facilitator)

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

Jack Hutcheson

0 references

Philippe Bouillet

0 references

Andreas Strasser

0 references

John C. Scatizzi

1 reference

31 January 2017

Emily Bickel

series ordinal

1 reference

31 January 2017

Nathaniel J. Brown

series ordinal

1 reference

31 January 2017

Harris Perlman

series ordinal

1 reference

31 January 2017

language of work or name

English

0 references

publication date

20 June 2005

1 reference

Journal of Experimental Medicine

31 January 2017

published in

1 reference

31 January 2017

volume

201

1 reference

31 January 2017

1 reference

31 January 2017

page(s)

1949–1960

1 reference

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 January 2017

cites work

1 reference

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BAD is a pro-survival factor prior to activation of its pro-apoptotic function

17 March 2017

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Cell death: critical control points

17 March 2017

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

17 March 2017

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

17 March 2017

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Integral role of Noxa in p53-mediated apoptotic response

17 March 2017

1 reference

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

17 March 2017

1 reference

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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

17 March 2017

1 reference

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

17 March 2017

1 reference

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

17 March 2017

1 reference

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Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

17 March 2017

1 reference

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

17 March 2017

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

17 March 2017

1 reference

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Bcl-2 and Bax function independently to regulate cell death

17 March 2017

1 reference

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

17 March 2017

1 reference

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

17 March 2017

1 reference

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The pathophysiology of mitochondrial cell death

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Mitochondria and apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

7 April 2017

1 reference

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

7 April 2017

1 reference

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The Bcl-2 protein family: arbiters of cell survival

7 April 2017

1 reference

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

7 April 2017

1 reference

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The role of BH3-only proteins in the immune system

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

T-lymphocyte death during shutdown of an immune response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Apoptosis in the development and maintenance of the immune system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

29 September 2017

1 reference

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

The 'harmless' release of cytochrome c.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

BH3-Only proteins-essential initiators of apoptotic cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Mcl-1 deficiency results in peri-implantation embryonic lethality

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

The proto-oncogene Bcl-2 and its role in regulating apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Bcl-2 and the ICE family of apoptotic regulators: making a connection.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041484

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041484

BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084%2FJEM.20041484

Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212027

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/15967824

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/15967824

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15967824

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

31 January 2017

0 references

1 reference