Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation (Q28513591)

25 January 2017

title

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation (English)

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Transforming growth factor, beta receptor I

25 January 2017

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Transforming growth factor, beta 1

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DNA-binding protein inhibitor ID-1

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Bone morphogenetic protein 2

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Mitogen-activated protein kinase 8

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SMAD specific E3 ubiquitin protein ligase 1

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Motozo Yamashita

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25 January 2017

Sai-Xia Ying

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25 January 2017

Gen-Mu Zhang

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25 January 2017

Cuiling Li

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25 January 2017

Steven Y. Cheng

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25 January 2017

Chu-Xia Deng

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25 January 2017

Ying E. Zhang

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25 January 2017

language of work or name

English

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publication date

8 April 2005

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25 January 2017

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25 January 2017

volume

121

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25 January 2017

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25 January 2017

page(s)

101–113

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Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects

25 January 2017

cites work

1 reference

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Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

19 March 2017

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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

19 March 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

19 March 2017

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

19 March 2017

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Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation

19 March 2017

1 reference

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

19 March 2017

1 reference

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AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element

19 March 2017

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

19 March 2017

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

19 March 2017

1 reference

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Signal transduction by the JNK group of MAP kinases

19 March 2017

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

19 March 2017

1 reference

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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation

19 March 2017

1 reference

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

19 March 2017

1 reference

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Smads bind directly to the Jun family of AP-1 transcription factors

19 March 2017

1 reference

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

19 March 2017

1 reference

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Function of WW domains as phosphoserine- or phosphothreonine-binding modules

19 March 2017

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Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta

19 March 2017

1 reference

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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

19 March 2017

1 reference

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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

19 March 2017

1 reference

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Novel regulators of bone formation: molecular clones and activities

19 March 2017

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TGF beta signals through a heteromeric protein kinase receptor complex

19 March 2017

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

19 March 2017

1 reference

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

7 April 2017

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How cells read TGF-beta signals

7 April 2017

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7 April 2017

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ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome

29 September 2017

1 reference

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Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo

29 September 2017

1 reference

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Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice

29 September 2017

1 reference

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Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation

29 September 2017

1 reference

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Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

29 September 2017

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E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

29 September 2017

1 reference

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RUNX transcription factors as key targets of TGF-beta superfamily signaling

29 September 2017

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Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

29 September 2017

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Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

29 September 2017

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Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators

29 September 2017

1 reference

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TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

Reaching a genetic and molecular understanding of skeletal development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

NeW wrinkles for an old domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

27 November 2018

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12 December 2020

The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity

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12 December 2020

Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells

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12 December 2020

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

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12 December 2020

10.1016/J.CELL.2005.01.035

Identifiers

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