Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size (Q28304000)

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

GOA release 2020-03-11

Jill Lindner

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Mark A Magnuson

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Yanyun Gu

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Anil Kumar

series ordinal

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Weiping Yuan

series ordinal

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language of work or name

English

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publication date

March 2011

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827-37

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start time

30 August 2021

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

29 September 2017

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Intrinsic regulators of pancreatic beta-cell proliferation

29 September 2017

1 reference

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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

29 September 2017

1 reference

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29 September 2017

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Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

29 September 2017

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29 September 2017

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Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

29 September 2017

1 reference

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An encapsulation system for the immunoisolation of pancreatic islets

29 September 2017

1 reference

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Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics

29 September 2017

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Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Very slow turnover of beta-cells in aged adult mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Type 2 diabetes-a matter of beta-cell life and death?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046843

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21266327

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB10-1194

1 reference

Internet Archive ID

pubmed-PMC3046843

0 references

1 reference

1 reference

PubMed publication ID

21266327

1 reference