IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC (Q28267857)

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English	IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC	scientific article

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scholarly article

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IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC (English)

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Osvaldo Martinez

3

object named as

Osvaldo Martinez

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author name string

Madhu Ramaswamy

1

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Elena V Efimova

2

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Nirupama U Mulherkar

4

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Surya P Singh

5

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Bellur S Prabhakar

6

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language of work or name

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publication date

12 August 2004

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23

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36

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6083-94

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Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3

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21 January 2018

Apoptosis control by death and decoy receptors

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21 January 2018

The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis.

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21 January 2018

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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21 January 2018

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

1 reference

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21 January 2018

DENN, a novel human gene differentially expressed in normal and neoplastic cells

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The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22

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Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

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TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

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21 January 2018

IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs

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21 January 2018

Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

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21 January 2018

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

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Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

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FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts

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Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

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Induction of marked apoptosis in mammalian cancer cell lines by antisense DNA treatment to abolish expression of DENN (differentially expressed in normal and neoplastic cells)

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21 January 2018

Antisense abrogation of DENN expression induces apoptosis of leukemia cells in vitro, causes tumor regression in vivo and alters the transcription of genes involved in apoptosis and the cell cycle

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21 January 2018

A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins

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Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

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21 January 2018

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

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TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme

1 reference

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MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

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21 January 2018

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

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21 January 2018

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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21 January 2018

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

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21 January 2018

Rab3A small GTP-binding protein in Ca(2+)-dependent exocytosis

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Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction

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Caspases: enemies within

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Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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Identification and characterization of a new member of the TNF family that induces apoptosis

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TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells

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Target protease specificity of the viral serpin CrmA. Analysis of five caspases

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A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

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Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB

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Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells

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10.1038/SJ.ONC.1207804

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