Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease (Q28114818)

3 January 2017

title

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease (English)

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3 January 2017

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V. O. Ona

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3 January 2017

M. Li

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3 January 2017

J. P. Vonsattel

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3 January 2017

L. J. Andrews

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3 January 2017

S. Q. Khan

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3 January 2017

W. M. Chung

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3 January 2017

A. S. Frey

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3 January 2017

A. S. Menon

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3 January 2017

X. J. Li

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3 January 2017

P. E. Stieg

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3 January 2017

J. Yuan

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3 January 2017

J. B. Penney

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3 January 2017

A. B. Young

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3 January 2017

J. H. Cha

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3 January 2017

R. M. Friedlander

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3 January 2017

language of work or name

English

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publication date

20 May 1999

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3 January 2017

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volume

399

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3 January 2017

issue

6733

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3 January 2017

page(s)

263–267

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

3 January 2017

cites work

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Human ICE/CED-3 protease nomenclature

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Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

21 January 2018

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Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control

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Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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Differential expression of normal and mutant Huntington's disease gene alleles

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Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneurons

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A cellular model that recapitulates major pathogenic steps of Huntington's disease

21 January 2018

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Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

21 January 2018

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Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

21 January 2018

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Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

21 January 2018

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The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

21 January 2018

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Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis

21 January 2018

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Interleukin-1, nitric oxide and reactive astrocytes

21 January 2018

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Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity

21 January 2018

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Inhibition of ICE slows ALS in mice

21 January 2018

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Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons.

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

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Dimensions Publication ID

3 January 2017

1035923952

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