The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme (Q27933334)

1 December 2016

title

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme (English)

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E2 ubiquitin-conjugating protein RAD6 YGL058W

1 December 2016

main subject

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E3 ubiquitin-protein ligase UBR1 YGR184C

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

R J Dohmen

R J

Dohmen

1 reference

22 October 2023

K Madura

series ordinal

author given names

author last names

Madura

1 reference

22 October 2023

B Bartel

series ordinal

author given names

author last names

Bartel

1 reference

22 October 2023

A Varshavsky

series ordinal

author given names

author last names

Varshavsky

1 reference

Proceedings of the National Academy of Sciences of the United States of America

22 October 2023

language of work or name

English

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publication date

15 August 1991

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published in

1 reference

The Role of Radiation (rad) Genes in Meiotic Recombination in Yeast

1 December 2016

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7351-5

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cites work

1 reference

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The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

20 March 2017

1 reference

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The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme

20 March 2017

1 reference

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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

20 March 2017

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Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

20 March 2017

1 reference

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The recognition component of the N-end rule pathway

20 March 2017

1 reference

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Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae

20 March 2017

1 reference

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The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6

20 March 2017

1 reference

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Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins

20 March 2017

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UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme

20 March 2017

1 reference

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Inhibition of the N-end rule pathway in living cells

20 March 2017

1 reference

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New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

20 March 2017

1 reference

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In vivo half-life of a protein is a function of its amino-terminal residue

20 March 2017

1 reference

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

20 March 2017

1 reference

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RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates

7 April 2017

1 reference

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Domain structure and functional analysis of the carboxyl-terminal polyacidic sequence of the RAD6 protein of Saccharomyces cerevisiae

29 September 2017

1 reference

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Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

29 September 2017

1 reference

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Analysis of meiosis-defective mutations in yeast by physical monitoring of recombination.

29 September 2017

1 reference

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Ubiquitin-mediated protein degradation.

29 September 2017

1 reference

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How are substrates recognized by the ubiquitin-mediated proteolytic system?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=52293

Universality and structure of the N-end rule

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=52293

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

29 September 2017

1 reference

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Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

29 September 2017

1 reference

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Expression of the Saccharomyces cerevisiae DNA repair gene RAD6 that encodes a ubiquitin conjugating enzyme, increases in response to DNA damage and in meiosis but remains constant during the mitotic cell cycle

29 September 2017

1 reference

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Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition

29 September 2017

1 reference

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Cloning of the Schwanniomyces occidentalis glucoamylase gene (GAM1) and its expression in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=52293

The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity

29 September 2017

1 reference

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Several mammalian ubiquitin carrier proteins, but not E2(20K), are related to the 20-kDa yeast E2, RAD6.

2 June 2018

1 reference

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cis-trans recognition and subunit-specific degradation of short-lived proteins

2 June 2018

1 reference

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A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis

2 June 2018

1 reference

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The degradation signal in a short-lived protein

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=52293

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites

27 November 2018

1 reference

12 December 2020

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins

1 reference

12 December 2020

Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase

1 reference

12 December 2020

Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme

1 reference

12 December 2020

Recombination and mutagenesis in rad6 mutants of Saccharomyces cerevisiae: evidence for multiple functions of the RAD6 gene

1 reference

12 December 2020

Specificity and frequency of ultraviolet-induced reversion of an iso-1-cytochrome c ochre mutant in radiation-sensitive strains of yeast

1 reference

12 December 2020

The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast

1 reference

12 December 2020

Naming a targeting signal

1 reference

12 December 2020

Functional heterogeneity of ubiquitin carrier proteins

1 reference

12 December 2020

Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.88.16.7351

1 reference

ADS bibcode

1991PNAS...88.7351D

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1 reference

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