Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland (Q27315980)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland (English)

1 reference

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18 March 2020

1 reference

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18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Jane E Visvader

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Nathan J Godde

1 reference

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18 March 2020

Lorey K Smith

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Ryan C Galea

series ordinal

1 reference

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18 March 2020

language of work or name

English

0 references

publication date

22 May 2014

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18 March 2020

1 reference

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18 March 2020

volume

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18 March 2020

issue

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18 March 2020

page(s)

e1004323

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Creative Commons Attribution 4.0 International

18 March 2020

start time

22 May 2014

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

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21 March 2017

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The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

21 March 2017

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Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

21 March 2017

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Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli

21 March 2017

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hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells

21 March 2017

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Mammalian Scribble forms a tight complex with the betaPIX exchange factor

21 March 2017

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Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix

21 March 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 March 2017

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Putting tumours in context

21 March 2017

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Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 March 2017

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The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

21 March 2017

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Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

21 March 2017

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hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

21 March 2017

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BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

21 March 2017

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Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape

21 March 2017

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Scribble interacts with beta-catenin to localize synaptic vesicles to synapses

21 March 2017

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Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration

21 March 2017

1 reference

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Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

21 March 2017

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Generation of a functional mammary gland from a single stem cell

21 March 2017

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An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth

7 April 2017

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CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells.

28 September 2017

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Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.

28 September 2017

1 reference

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Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

28 September 2017

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Sustained activation of the HER1-ERK1/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue

28 September 2017

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Pregnancy-induced changes in breast cancer risk

28 September 2017

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Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development

28 September 2017

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28 September 2017

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Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

28 September 2017

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Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

28 September 2017

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What is the malignant nature of human ductal carcinoma in situ?

28 September 2017

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hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer

28 September 2017

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The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble

28 September 2017

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Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis

28 September 2017

1 reference

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Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

28 September 2017

1 reference

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The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.

28 September 2017

1 reference

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Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Dual role of Cdc42 in spindle orientation control of adherent cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Drosophila asymmetric division, polarity and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

From cells to organs: building polarized tissue.

28 September 2017

1 reference

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Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

28 September 2017

1 reference

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Human scribble accumulates in colorectal neoplasia in association with an altered distribution of beta-catenin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The duration of ERK1/2 activity determines the activation of c-Fos and Fra-1 and the composition and quantitative transcriptional output of AP-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Biological variables and prognosis of DCIS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

28 September 2017

1 reference

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The preneoplastic phenotype in murine mammary tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma

28 September 2017

1 reference

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Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts

28 September 2017

1 reference

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ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Identification of gene expression profiles that predict the aggressive behavior of breast cancer cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Cre-mediated gene deletion in the mammary gland

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

A βPIX-PAK2 complex confers protection against Scrib-dependent and cadherin-mediated apoptosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Activated neu induces rapid tumor progression.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Cell contacts in the mouse mammary gland: i. Normal gland in postnatal development and the secretory cycle. 1973.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Mammary tumor phenotypes in wild-type aging female FVB/N mice with pituitary prolactinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Mitotic spindle misorientation in cancer--out of alignment and into the fire

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4031063

Parity, age at first and last birth, and risk of breast cancer: A population-based study in Sweden

28 November 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004323

The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24852022

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24852022

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1004323

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

24852022

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24852022%20AND%20SRC:MED&resulttype=core&format=json