Targeting Cdc42 in cancer (Q27028075)

Expert Opinion on Therapeutic Targets

published in

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1263-73

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14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

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Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer

21 March 2017

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IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

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21 March 2017

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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

21 March 2017

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

21 March 2017

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 March 2017

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 March 2017

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RhoGDI2 is an invasion and metastasis suppressor gene in human cancer

21 March 2017

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GEFs: structural basis for their activation of small GTP-binding proteins

21 March 2017

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IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells

21 March 2017

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Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis

21 March 2017

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Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42

21 March 2017

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D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness

21 March 2017

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CZH proteins: a new family of Rho-GEFs

21 March 2017

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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

21 March 2017

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The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

21 March 2017

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Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

21 March 2017

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Hyperactive Ras in developmental disorders and cancer

21 March 2017

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7 April 2017

RHO-GTPases and cancer

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An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

7 April 2017

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Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity

7 April 2017

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Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells

7 April 2017

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Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.

28 September 2017

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P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma

28 September 2017

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Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

28 September 2017

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Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

28 September 2017

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Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility

28 September 2017

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Cdc42 promotes transendothelial migration of cancer cells through β1 integrin

28 September 2017

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Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis

28 September 2017

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A tumor suppressor role for srGAP3 in mammary epithelial cells

28 September 2017

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The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

28 September 2017

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p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

28 September 2017

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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting

28 September 2017

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Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

28 September 2017

1 reference

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Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

28 September 2017

PAKs in human disease

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P21-activated kinase 4 overexpression in metastatic gastric cancer patients

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

The R(h)oads to Stat3: Stat3 activation by the Rho GTPases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Signaling role of Cdc42 in regulating mammalian physiology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.

28 September 2017

1 reference

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Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42-mediated tubulogenesis controls cell specification

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Signaling through Rho GTPase pathway as viable drug target

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Pak protein kinases and their role in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Role of Rho GTPases in breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Current knowledge of the large RhoGAP family of proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Human RAS superfamily proteins and related GTPases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42: new roads to travel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Polarized distribution of IQGAP proteins in gastric parietal cells and their roles in regulated epithelial cell secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Rho family proteins: coordinating cell responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

SAGEmap: a public gene expression resource

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

A molecular network for de novo generation of the apical surface and lumen

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

RhoGDI is required for Cdc42-mediated cellular transformation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

A novel Cdc42Hs mutant induces cellular transformation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

CDC-42 controls early cell polarity and spindle orientation in C. elegans

31 May 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Cell type-specific functions of Rho GTPases revealed by gene targeting in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Tissue-specific variations in the expression and regulation of the small GTP-binding protein Rho.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.828037

Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Accessibility of the c-Src SH2-domain for binding is increased during mitosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3937847

Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer

28 November 2018

1 reference

12 December 2020

Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis

1 reference

12 December 2020

Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma

1 reference

12 December 2020

Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors

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12 December 2020

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA

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12 December 2020

10.1517/14728222.2013.828037

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

23957315

1 reference