Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma (Q26771855)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Maria-Luisa Giudici

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Robin F Irvine

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

language of work or name

English

0 references

publication date

2 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26710750%20AND%20SRC:MED&resulttype=core&format=json

Advances in Biological Regulation

3 March 2020

published in

2 references

PubMed

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3 March 2020

volume

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3 March 2020

page(s)

47-50

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Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain

3 March 2020

cites work

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The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases

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PIP4K and the role of nuclear phosphoinositides in tumour suppression

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Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta

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Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors

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Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines

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PtdIns5P and Pin1 in oxidative stress signaling

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Exploring phosphatidylinositol 5-phosphate 4-kinase function

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Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta

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Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate

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PI(5)P regulates autophagosome biogenesis

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The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

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Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

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A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.

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Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage

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Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIalpha and IIbeta and a partial nuclear localization of the IIalpha isoform

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PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha

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Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

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PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.

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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

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Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

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Arsenic trioxide induces abnormal mitotic spindles through a PIP4KIIγ/Rho pathway

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7 January 2021

Nuclear phosphoinositides and their impact on nuclear functions

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7 January 2021

Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling.

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PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation

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7 January 2021

Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice

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Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron

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Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation

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A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

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Phosphatidylinositol 5-phosphate is a second messenger important for cell migration.

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