LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation (Q24672926)

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Ok-Hee Lee

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Young Bong Choi

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Changwon Park

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Hyunsook Lee

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Yungdae Yun

Journal of Experimental Medicine

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language of work or name

English

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publication date

17 November 2003

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published in

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volume

198

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issue

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page(s)

1463-73

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cites work

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Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation

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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

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FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

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LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

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Structural basis for the binding of proline-rich peptides to SH3 domains

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

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In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

28 September 2017

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TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts

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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

28 September 2017

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Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases

28 September 2017

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28 September 2017

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Recognition and specificity in protein tyrosine kinase-mediated signalling

28 September 2017

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Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

28 September 2017

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Non-receptor protein tyrosine kinases as immune targets of viruses

28 September 2017

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A kinase-independent function of Lck in potentiating antigen-specific T cell activation

30 May 2018

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Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

30 May 2018

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The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

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LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

21 January 2018

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Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs

21 January 2018

1 reference

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The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production

21 January 2018

1 reference

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28 November 2018

Identifiers

DOI

10.1084/JEM.20030232

1 reference

1 reference

1 reference

PubMed publication ID

14610044

1 reference