The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18 (Q24303678)

activation of GTPase activity

GOA release 2020-03-11

1 reference

Dedicator of cytokinesis protein 7

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Mitsuko Watabe-Uchida

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Keisha A John

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Justyna A Janas

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Sarah E Newey

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Linda Van Aelst

Neuronal generation, migration, and differentiation in the mouse hippocampal primoridium as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation

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language of work or name

English

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publication date

21 September 2006

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727-39

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cites work

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stathmin, a gene enriched in the amygdala, controls both learned and innate fear

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APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity

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Polarity proteins in axon specification and synaptogenesis

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Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

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NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

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Key Regulators in Neuronal Polarity

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A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon

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Isolation of Rho GTPase effector pathways during axon development.

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Lentiviral delivery of RNAi in hippocampal neurons

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Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

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Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

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Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP

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Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance

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DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells

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Microtubule reconfiguration during axogenesis

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Regulated nuclear import of Rel proteins in the Drosophila immune response

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Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

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Rac GTPases control axon growth, guidance and branching

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Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

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Centrosome localization determines neuronal polarity.

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Neuronal polarity: microtubules strike back

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PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.

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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

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Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

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Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

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The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

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Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

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PIP3 is involved in neuronal polarization and axon formation.

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Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation

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Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16

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Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway

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Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

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MOCA induces membrane spreading by activating Rac1.

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Mechanical tension can specify axonal fate in hippocampal neurons

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Regulation of leading edge microtubule and actin dynamics downstream of Rac1

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Activation of Rac1 by a Crk SH3-binding protein, DOCK180

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Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

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Stathmin-tubulin interaction gradients in motile and mitotic cells

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The role of local actin instability in axon formation

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Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

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CZH proteins: a new family of Rho-GEFs

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Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin.

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Changes in microtubule number and length during axon differentiation

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