siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle (Q24295160)

Insulin receptor substrate 2

1 reference

AKT serine/threonine kinase 2

1 reference

Insulin receptor substrate 1

1 reference

lipid homeostasis

1 reference

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

Heikki A Koistinen

0 references

Anna Krook

0 references

Juleen R Zierath

0 references

Karim Bouzakri

0 references

Anna Zachrisson

series ordinal

0 references

Lubna Al-Khalili

series ordinal

0 references

Bei B Zhang

series ordinal

0 references

language of work or name

English

0 references

publication date

July 2006

0 references

0 references

0 references

0 references

89-96

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

WY-14643 and 9- cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

WY-14643 and 9-cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: differential effect in myotubes from healthy subjects and Type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin action and insulin resistance in human skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

RNA interference-mediated reduction in GLUT1 inhibits serum-induced glucose transport in primary human skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Role of Akt/protein kinase B in metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A cellular model system of differentiated human myotubes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAP AS160.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

ERK1/2 inhibition prevents contraction-induced increase in plasma membrane FAT/CD36 content and FA uptake in rodent muscle

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

From mice to men: insights into the insulin resistance syndromes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CMET.2006.04.008

7 January 2021

10.1016/J.CMET.2006.04.008

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

release_xk3onlnl6zfptbfyk73cajgdma

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xk3onlnl6zfptbfyk73cajgdma

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16814735

1 reference

Consolidated OpenCitations Corpus – April 2017