ERCC excision repair 5, endonuclease (Q21112337)

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mammalian protein found in Homo sapiens

ERCC5
XPG-complementing protein
excision repair cross-complementing rodent repair deficiency, complementation group 5
Xeroderma pigmentosum group G-complementing protein
DNA excision repair protein ERCC-5
xeroderma pigmentosum, complementation group G
excision repair cross-complementation group 5
DNA repair protein complementing XP-G cells
xeroderma pigmentosum, complementation group G protein

Language	Label	Description	Also known as
English	ERCC excision repair 5, endonuclease	mammalian protein found in Homo sapiens	ERCC5 XPG-complementing protein excision repair cross-complementing rodent repair deficiency, complementation group 5 Xeroderma pigmentosum group G-complementing protein DNA excision repair protein ERCC-5 xeroderma pigmentosum, complementation group G excision repair cross-complementation group 5 DNA repair protein complementing XP-G cells xeroderma pigmentosum, complementation group G protein

Statements

1 reference

16 January 2019

UniProt protein ID

PIN-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28715

5'-3' exonuclease, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28715

XPG/Rad2 endonuclease, eukaryotes

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28715

XPG N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

XPG-I domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

XPG conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helix-hairpin-helix motif, class 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method or standard

1 reference

8 April 2019

Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

hydrolase activity, acting on ester bonds

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

protein N-terminus binding

determination method or standard

1 reference

8 April 2019

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

bubble DNA binding

determination method or standard

1 reference

8 April 2019

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

protein binding

determination method or standard

5 references

8 April 2019

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

catalytic activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

double-stranded DNA binding

determination method or standard

endodeoxyribonuclease activity

determination method or standard

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

24 April 2018

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

24 April 2018

XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

RNA polymerase II complex binding

determination method or standard

1 reference

8 April 2019

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

single-stranded DNA binding

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

endodeoxyribonuclease activity

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

8 April 2019

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

RNA polymerase II, holoenzyme

determination method or standard

1 reference

24 April 2018

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

transcription factor TFIIH holo complex

determination method or standard

1 reference

24 April 2018

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

DNA replication factor A complex

determination method or standard

1 reference

8 April 2019

RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

determination method or standard

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

24 April 2018

Ultraviolet-induced movement of the human DNA repair protein, Xeroderma pigmentosum type G, in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair complex

determination method or standard

1 reference

8 April 2019

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Ultraviolet-induced movement of the human DNA repair protein, Xeroderma pigmentosum type G, in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

biological process

negative regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

Suppression of UV-induced apoptosis by the human DNA repair protein XPG

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

determination method or standard

1 reference

8 April 2019

An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, DNA incision

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

determination method or standard

response to UV-C

determination method or standard

1 reference

8 April 2019

UV-induced apoptosis in XPG-deficient fibroblasts involves activation of CD95 and caspases but not p53

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair

determination method or standard

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, preincision complex stabilization

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, preincision complex assembly

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, DNA incision, 5'-to lesion

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method or standard

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method or standard

3 references

10 September 2018

Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

10 September 2018

XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28715&geneProductId=UniProtKB:P28715

determination method or standard

nucleotide-excision repair, DNA incision, 3'-to lesion

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28715

determination method or standard

Identifiers

RefSeq protein ID

1 reference

16 November 2018

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000347978

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000347978

ENSP00000365121

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000365121

ENSP00000442117

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000442117

ENSP00000436083

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000436083

ENSP00000473384

1 reference

ensembl Release 95

Ensembl protein ID

ENSP00000473384

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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