DDB1 and CUL4 associated factor 1 (Q21112163)

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mammalian protein found in Homo sapiens

Vpr-binding protein
HIV-1 Vpr-binding protein
Vpr (HIV-1) binding protein
DDB1- and CUL4-associated factor 1
vpr-interacting protein
protein VPRBP
serine/threonine-protein kinase VPRBP
DCAF1
VprBP
2.7.11.1

Language	Label	Description	Also known as
English	DDB1 and CUL4 associated factor 1	mammalian protein found in Homo sapiens	Vpr-binding protein HIV-1 Vpr-binding protein Vpr (HIV-1) binding protein DDB1- and CUL4-associated factor 1 vpr-interacting protein protein VPRBP serine/threonine-protein kinase VPRBP DCAF1 VprBP 2.7.11.1

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4B6

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4B6

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4B6

VPRBP/DCAF1 family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4B6

LIS1 homology motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

histone kinase activity (H2A-T120 specific)

determination method

1 reference

27 February 2018

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

protein binding

determination method

8 references

8 April 2019

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Global landscape of HIV-human protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Structural basis of lentiviral subversion of a cellular protein degradation pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

estrogen receptor binding

determination method

1 reference

27 February 2018

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

COP9 signalosome

determination method

1 reference

8 April 2019

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

27 February 2018

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

27 February 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

fibrillar center

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

1 reference

27 February 2018

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

Cul4-RING E3 ubiquitin ligase complex

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4B6&geneProductId=UniProtKB:Q9Y4B6

determination method

cell competition in a multicellular organism

determination method

1 reference

8 April 2019

Involvement of Lgl and Mahjong/VprBP in cell competition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4B6

determination method

EC enzyme number

2.7.11.1

1 reference

14 November 2015

http://www.uniprot.org/uniprot/Q9Y4B6.txt?version=121

LIS1 homology motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y4B6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000338857

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000338857

ENSP00000393183

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393183

ENSP00000421724

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421724

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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