Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials (Q56379943)

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scholarly article by Adelaide S M Dennis et al published June 2018 in Antimicrobial Agents and Chemotherapy

Language	Label	Description	Also known as
English	Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials	scholarly article by Adelaide S M Dennis et al published June 2018 in Antimicrobial Agents and Chemotherapy

Statements

scholarly article

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Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials (English)

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object named as

Adele M Lehane

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object named as

Kiaran Kirk

5

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author name string

Adelaide S M Dennis

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Melanie C Ridgway

3

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John P Holleran

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language of work or name

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publication date

June 2018

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Antimicrobial Agents and Chemotherapy

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62

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6

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Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

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Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

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Differential time-dependent volumetric and surface area changes and delayed induction of new permeation pathways in P. falciparum-infected hemoglobinopathic erythrocytes

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A high-sensitivity HPLC assay for measuring intracellular Na(+) and K(+) and its application to Plasmodium falciparum infected erythrocytes

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Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum

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The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

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A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609.

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(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

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Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

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Diverse chemotypes disrupt ion homeostasis in the Malaria parasite

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Spiroindolone KAE609 for falciparum and vivax malaria

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Identification of inhibitors of Plasmodium falciparum gametocyte development

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High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography

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Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite

1 reference

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Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

1 reference

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Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

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Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling

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The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector

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Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values.

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Identifiers

10.1128/AAC.00087-18

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