KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals (Q28507994)

24 January 2017

title

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals (English)

1 reference

Protein phosphatase 3, catalytic subunit, alpha isoform

24 January 2017

main subject

1 reference

Kinase suppressor of ras 2

GOA release 2020-03-11

1 reference

Kinase suppressor of ras 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Michele K. Dougherty

1 reference

24 January 2017

Daniel A. Ritt

1 reference

24 January 2017

Ming Zhou

1 reference

24 January 2017

Suzanne I. Specht

1 reference

24 January 2017

Daniel M. Monson

1 reference

24 January 2017

Timothy D. Veenstra

1 reference

24 January 2017

Deborah K. Morrison

1 reference

24 January 2017

publication date

26 June 2009

1 reference

24 January 2017

1 reference

24 January 2017

1 reference

24 January 2017

1 reference

24 January 2017

page(s)

652–662

1 reference

Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5

24 January 2017

cites work

1 reference

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

19 March 2017

1 reference

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Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling

19 March 2017

1 reference

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

19 March 2017

1 reference

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C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

A second calcineurin binding site on the NFAT regulatory domain

19 March 2017

1 reference

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Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

19 March 2017

1 reference

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Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

19 March 2017

1 reference

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Two-site interaction of nuclear factor of activated T cells with activated calcineurin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

19 March 2017

1 reference

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Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

19 March 2017

1 reference

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KSR modulates signal propagation within the MAPK cascade

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

KSR, a novel protein kinase required for RAS signal transduction

19 March 2017

1 reference

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

19 March 2017

1 reference

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

7 April 2017

1 reference

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Transcriptional regulation by calcium, calcineurin, and NFAT

7 April 2017

1 reference

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Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins

7 April 2017

1 reference

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The MEK/ERK cascade: from signaling specificity to diverse functions

29 September 2017

1 reference

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Scaffold proteins in MAP kinase signaling: more than simple passive activating platforms.

29 September 2017

1 reference

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hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Calcium activation of ERK mediated by calmodulin kinase I.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Calcineurin anchoring and cell signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Integration of calcium and Ras signalling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

KSR is a scaffold required for activation of the ERK/MAPK module

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

29 September 2017

1 reference

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Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway

29 September 2017

1 reference

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Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

29 September 2017

1 reference

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Calcium, calcineurin, and the control of transcription

29 September 2017

1 reference

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Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

The protein kinase KSR interacts with 14-3-3 protein and Raf.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Identification of the major phosphorylation sites of the Raf-1 kinase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

RAS oncogenes: the first 30 years.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2737517

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19560418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Blockade of NFAT activation by the second calcineurin binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19560418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2009.06.001

1 reference

1 reference

1 reference

1 reference