Milameline
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Clinical data | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.220.595 |
Chemical and physical data | |
Formula | C8H14N2O |
Molar mass | 154.213 g·mol−1 |
3D model (JSmol) | |
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Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.[1]
- Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.[2]
See also
References
- ^ Sedman AJ, Bockbrader H, Schwarz RD (1995). "Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease". Life Sciences. 56 (11–12): 877–882. doi:10.1016/0024-3205(95)00023-Y. PMID 10188788.
- ^ Broadley KJ, Kelly DR (2001). "Muscarinic Receptor Agonists and Antagonists". Molecules. 6 (3): 142–193. doi:10.3390/60300142. ISSN 1420-3049. PMC 6236374.
Categories:
- Articles with short description
- Short description matches Wikidata
- Drugs not assigned an ATC code
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Muscarinic agonists
- Aldoximes
- Tetrahydropyridines
- Abandoned drugs
- Oxime ethers