(Q42165242)

17 October 2017

title

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase (English)

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17 October 2017

Thomas Kukar

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Jens Wiltfang

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Eva Czirr

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17 October 2017

Barbara A Cottrell

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17 October 2017

Stefanie Leuchtenberger

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17 October 2017

Thomas B Ladd

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17 October 2017

Hermann Esselmann

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17 October 2017

Sabine Paul

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17 October 2017

Robert Schubenel

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17 October 2017

Justin W Torpey

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17 October 2017

Claus U Pietrzik

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17 October 2017

Todd E Golde

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17 October 2017

Karlheinz Baumann

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17 October 2017

Edward H Koo

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17 October 2017

Sascha Weggen

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17 October 2017

language of work or name

English

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publication date

21 April 2008

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Journal of Biological Chemistry

17 October 2017

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inferred from page(s)

published in

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17 October 2017

volume

283

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17 October 2017

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17 October 2017

page(s)

17049-17054

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Disease modifying therapy for AD?

17 October 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

The gamma-secretase complex: membrane-embedded proteolytic ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Purification and characterization of the human gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

The same gamma-secretase accounts for the multiple intramembrane cleavages of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802912200

21 January 2018

Identifiers

DOI

10.1074/JBC.M802912200

1 reference

17 October 2017

1 reference