(Q40061988)

English

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

scientific article published on 24 October 2007

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Europe PubMed Central

PubMed publication ID

17 September 2017

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Alzheimer's disease

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Christian Haass

11

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Christian Haass

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author name string

Richard M Page

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Karlheinz Baumann

2

1 reference

Europe PubMed Central

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17 September 2017

Masanori Tomioka

3

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Blanca I Pérez-Revuelta

4

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Akio Fukumori

5

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Europe PubMed Central

PubMed publication ID

17 September 2017

Helmut Jacobsen

6

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Alexander Flohr

7

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Thomas Luebbers

8

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Laurence Ozmen

9

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Harald Steiner

10

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Europe PubMed Central

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17 September 2017

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publication date

24 October 2007

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Europe PubMed Central

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17 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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17 September 2017

283

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Europe PubMed Central

PubMed publication ID

17 September 2017

2

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Europe PubMed Central

PubMed publication ID

17 September 2017

677-683

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Europe PubMed Central

PubMed publication ID

17 September 2017

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Strategies for disease modification in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Purification and characterization of the human gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Mean age of onset in familial Alzheimer's disease is determined by amyloid beta 42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708754200

21 January 2018

Identifiers

10.1074/JBC.M708754200

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

release_pk46enn7bbde3kx2mzjv3gtkde

1 reference

https://api.fatcat.wiki/v0/release/pk46enn7bbde3kx2mzjv3gtkde

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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