(Q39978729)

16 September 2017

title

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity (English)

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16 September 2017

author name string

Lucía Chávez-Gutiérrez

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16 September 2017

Alexandra Tolia

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16 September 2017

Elke Maes

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16 September 2017

Tong Li

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16 September 2017

Philip C Wong

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16 September 2017

Bart de Strooper

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16 September 2017

language of work or name

English

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publication date

23 May 2008

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

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16 September 2017

page(s)

20096-20105

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Gamma-secretase: proteasome of the membrane?

16 September 2017

cites work

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

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21 January 2018

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Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

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21 January 2018

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21 January 2018

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21 January 2018

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

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Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

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Recombinant adenovirus is an appropriate vector for endocytotic protein trafficking studies in cultured neurons

21 January 2018

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Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

21 January 2018

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21 January 2018

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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

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gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

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Nicastrin binds to membrane-tethered Notch

21 January 2018

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Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

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Crystal structure of the ectodomain of human transferrin receptor

21 January 2018

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HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.

21 January 2018

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Mechanism for multiple ligand recognition by the human transferrin receptor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803040200

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16 September 2017

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