(Q46646587)

23 December 2017

title

Nicastrin functions as a gamma-secretase-substrate receptor (English)

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23 December 2017

Thomas Südhof

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23 December 2017

Katsuhiko Tabuchi

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23 December 2017

author name string

Sanjiv Shah

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23 December 2017

Sheu-Fen Lee

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23 December 2017

Yi-Heng Hao

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23 December 2017

Cong Yu

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23 December 2017

Quincey LaPlant

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23 December 2017

Haydn Ball

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23 December 2017

Charles E Dann

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23 December 2017

Gang Yu

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23 December 2017

language of work or name

English

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publication date

1 August 2005

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23 December 2017

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23 December 2017

volume

122

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23 December 2017

issue

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23 December 2017

page(s)

435-447

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23 December 2017

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Synthesis of proteins by native chemical ligation

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Gamma-secretase: proteasome of the membrane?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Synthesis of native proteins by chemical ligation

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

CDD: a Conserved Domain Database for protein classification

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Expression of N-formylated proteins in Escherichia coli.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Nicastrin binds to membrane-tethered Notch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2005.05.022

Identifiers

DOI

10.1016/J.CELL.2005.05.022

1 reference

23 December 2017

1 reference

23 December 2017