(Q33807825)

29 July 2017

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title

mdm2: a bridge over the two tumour suppressors, p53 and Rb. (English)

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29 July 2017

D B Yap

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29 July 2017

J K Hsieh

series ordinal

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29 July 2017

F S Chan

series ordinal

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29 July 2017

X Lu

series ordinal

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

7681-7689

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Deletion of RB exons 24 and 25 causes low-penetrance retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The E2F transcription factor is a cellular target for the RB protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Physical interaction of the retinoblastoma protein with human D cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Wild-type p53 can inhibit oncogene-mediated focus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Presence of a potent transcription activating sequence in the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Wild-type p53 can down-modulate the activity of various promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

E2F-1-induced p53-independent apoptosis in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Human retinoblastoma susceptibility gene: cloning, identification, and sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Control of pRB phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Interaction between the retinoblastoma protein and the oncoprotein MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

The retinoblastoma gene product is reversibly dephosphorylated and bound in the nucleus in S and G2 phases during hypoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Overview of RB gene mutations in patients with retinoblastoma. Implications for clinical genetic screening

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202954

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202954

1 reference

Dimensions Publication ID

29 July 2017

1045257156

0 references

1 reference