| Protagonist | Carl Johnson |
| Main characters | Sean "Sweet" Johnson | Kendl Johnson | Frank Tenpenny† | Big Smoke (Melvin Harris)† | Wu Zi Mu | The Truth | Cesar Vialpando | Catalina† | Salvatore Leone† | Madd Dogg | Kent Paul | Eddie Pulaski† | Ken Rosenberg | Mike Toreno | Ryder (Lance Wilson)† | Jizzy B.† | OG Loc (Jeffrey Cross) | T-Bone Mendez† | Zero | Maccer | |
| Minor characters | Andre† |Benny† | Bettina | Berkley | Big Poppa† | Bogman | Claude | Construction Foreman† | Alan Crawford† | Derek | District Attorney | Dope | Dwaine | Emmet | Freddy† | Colonel Fuhrberger | Gal | Guppy | Hazer | Janitor | Jimmy Hernandez† | Jethro | Jose | Kane† | Maria Latore | Ran Fa Li | Little Bill | Little Lion† | Little Weasel† | Mike | Su Xi Mu | Ralph Pendelbury† | Marco Forelli† | Mickey† | Old Reece | Jimmy Silverman | Johnny Sindacco† | The Snakehead† | The Triad Leader | Sunny | Big Bear (Barry Thorne) | Tony | Vagos gang members (Running Dog)† | B Dup (Mark Wayne) | Mr. Whittaker | Pizza Clerk | Preacher Bishop† | Rival Pimp† | Sweet's Girlfriend | The Dossier Carrier† | The Informant† | The Journalist† | The Reporter† | Unnamed Burger Shot Employee | Unnamed Crack Whore | Gasso Employee | Alan Crawford's Female Associate† | Mafia Goon 1 | Forelli Crime Family's pilot† | C.R.A.S.H. Rookies† | Cesar's Informant | Salvatore Leone's Bodyguard | Tim† | Tammy† | Loco Low Co. Mechanic | Driving School Tutor | Ammu-Nation Clerk | Triad Assistant 1 | Triad Assistant 2 | Triad Mechanic | Jordan | Larry | Unnamed LVPD Officer | Ballas Snitch† | City Planning Department Receptionist |
| Girlfriends | Denise Robinson | Millie Perkins | Helena Wankstein | Katie Zhan | Michelle Cannes | Barbara Schternvart |
| Radio station characters | |
| Radio guests | The Truth | OG Loc (Jeffrey Cross) | Big Wayne | Darius Fontaine | Jenna Forbes | Cris Formage | Jack Howitzer | Michael Hunt | Jimmy | Fernando Martinez | Tim | Reed Tucker |
| Mentioned characters | Mary Alexander | Mike Andrews | Big Devil† | Bobby | CM Pink | Joey Leone | Tommy Vercetti | James Earl Cash | Mary Ellen | Herbie | Ho Chi | Beverly Johnson† | Brian Johnson† | Carl Johnson's Father | Ah Ah Kung | LB | Little Devil† | General Mills | Tony† | Jezz Torrent | Avrindar |
| Other characters | Fraser Ashley | Morgan August | G.M. Berlotti | Big Smilky | Dr. Diablo | Gern Blanston | Henry Bolt† | D. Claremont | John Craig | Mary Fortune | Frank Gold | Hammerfist | Philip K. Jones | Ed Karson | Turk Martin | Cluck Norris | Jane Pole | Brontosaurus Rex | Rochell'le | Jeremy Smith | Brian Van Ginsberg | Scott Wilson |
| Deleted characters | Officer Carver | Poncho | Psycho |
† denotes Deceased, Italics denotes a status determined by the player's choice
Characters in GTA San Andreas | Category:Characters in GTA San Andreas | Grand Theft Auto: San Andreas | Category:Characters |
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