OR1A1

OR1A1
Identifikatzaileak
Aliasak	OR1A1 (HUGO), OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
Kanpoko IDak	OMIM: 618046 MGI: 1333770 HomoloGene: 8219 GeneCards: OR1A1 OMA: OR1A1 - orthologs
Genearen kokapena (Giza)
Kr.	Kromosoma 17 (gizakia)
Amaiera	3.218.896 bp
Genearen kokapena (Sagua)
Kr.	Kromosoma 11 (sagua)
Amaiera	74.102.205 bp
RNA adierazpena eredua
	Gehien adierazita
	Barrabil;
	Erreferentziazko adierazpen datu gehiago
	Erreferentziazko adierazpen datu gehiago
Gene ontologia
Funtzio molekularra	seinaleen transdukzio aktibitatea ; olfactory receptor activity ; G proteina errezeptore akoplatuaren aktibitatea ;
Zelularen osagaia	zelula mintz ; mintza ; zelula-mintzaren osagai integrala ;
Prozesu biologikoa	sensory perception of smell ; seinale transdukzio ; erantzuna estimuluari ; detection of chemical stimulus involved in sensory perception of smell ; G proteina errezeptore akoplatuaren komunikazio bidea ;
	Iturburuak:Amigo / QuickGO
Ortologoak
	8383
	258706
	ENSG00000172146
	ENSMUSG00000070377
	Q9P1Q5
	NM_014565; NM_001386104
	NM_146711
	NP_055380
	Wikidata
Ikusi/Editatu giza genea	Ikusi/Editatu saguaren genea

OR1A1 (ingelesez: Olfactory receptor 1A1, "1A1 usaimenaren errezeptorea") proteina bat da, gizakien OR1A1 geneak kodetzen duena^[5].

Funtzioa

Usaimenaren errezeptoreek usaina jariatzen duten molekulekin elkarrekintza dute sudurrean, usaimen gisa ezagutzen duguna sortuz neuronak kitzikatzerakoan. Usaimenaren errezeptoreak G-proteinei lotutako errezeptoreen (GPCR) familia handi bateko kide dira. Guztiek partekatzen dute 7-transmintza domeinuko egitura bat hormonen eta neurotransmisoreen errezeptoreekin, eta usaimen seinaleen transdukzioaz arduratzen dira. Usaimenaren errezeptoreen gene familia genomako handiena da^[6].

Ligandoak

OR1A1 oso errezeptore zabala da, usaimenaren molekula askori erantzuten diolako^[7]^[8]. Fruitu zitrikoen usainak bereziki hartzen ditu^[9]^[10]:

(S)-(−)-zitronelal
Helional
Heptanal
Oktanal
Nonanal (heptanal/oktanal baino gutxiago)
Hidroxizitronelal
Zitral
Zitronelol (bi enantiomeroak, baina zitronelal baino gutxiago)
Dihidrojasmon
Tiolak

Erreferentziak

↑ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172146 - Ensembl, May 2017
↑ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070377 – Ensembl, May 2017
↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ (Ingelesez) Glusman, Gustavo; Sosinsky, Alona; Ben-Asher, Edna; Avidan, Nili; Sonkin, Dina; Bahar, Anita; Rosenthal, André; Clifton, Sandra et al.. (2000-01-15). «Sequence, Structure, and Evolution of a Complete Human Olfactory Receptor Gene Cluster» Genomics 63 (2): 227–245. doi:10.1006/geno.1999.6030. ISSN 0888-7543. (Noiz kontsultatua: 2021-04-28).
↑ «OR1A1 olfactory receptor family 1 subfamily A member 1 [Homo sapiens (human) - Gene - NCBI»] www.ncbi.nlm.nih.gov (Noiz kontsultatua: 2021-04-28).
↑ (Ingelesez) Saito, Harumi; Chi, Qiuyi; Zhuang, Hanyi; Matsunami, Hiroaki; Mainland, Joel D.. (2009-03-03). «Odor Coding by a Mammalian Receptor Repertoire» Science Signaling 2 (60): ra9–ra9. doi:10.1126/scisignal.2000016. ISSN 1945-0877. PMID 19261596. PMC PMC2774247. (Noiz kontsultatua: 2021-04-28).
↑ (Ingelesez) Block, Eric; Batista, Victor S.; Matsunami, Hiroaki; Zhuang, Hanyi; Ahmed, Lucky. (2017-05-10). «The role of metals in mammalian olfaction of low molecular weight organosulfur compounds» Natural Product Reports 34 (5): 529–557. doi:10.1039/C7NP00016B. ISSN 1460-4752. PMID 28471462. PMC PMC5542778. (Noiz kontsultatua: 2021-04-28).
↑ (Ingelesez) «Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2» Journal of Structural Biology 159 (3): 400–412. 2007-09-01 doi:10.1016/j.jsb.2007.04.013. ISSN 1047-8477. (Noiz kontsultatua: 2021-04-28).
↑ (Ingelesez) Audouze, Karine; Tromelin, Anne; Bon, Anne Marie Le; Belloir, Christine; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Brunak, Søren; Taboureau, Olivier. (2014-04-02). «Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome» PLOS ONE 9 (4): e93037. doi:10.1371/journal.pone.0093037. ISSN 1932-6203. PMID 24695519. PMC PMC3973694. (Noiz kontsultatua: 2021-04-28).

Kanpo estekak

Datuak: Q18032877

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172146 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070377 – Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] (Ingelesez) Glusman, Gustavo; Sosinsky, Alona; Ben-Asher, Edna; Avidan, Nili; Sonkin, Dina; Bahar, Anita; Rosenthal, André; Clifton, Sandra et al.. (2000-01-15). «Sequence, Structure, and Evolution of a Complete Human Olfactory Receptor Gene Cluster» Genomics 63 (2): 227–245. doi:10.1006/geno.1999.6030. ISSN 0888-7543. (Noiz kontsultatua: 2021-04-28).

[6] «OR1A1 olfactory receptor family 1 subfamily A member 1 [Homo sapiens (human) - Gene - NCBI»] www.ncbi.nlm.nih.gov (Noiz kontsultatua: 2021-04-28).

[7] (Ingelesez) Saito, Harumi; Chi, Qiuyi; Zhuang, Hanyi; Matsunami, Hiroaki; Mainland, Joel D.. (2009-03-03). «Odor Coding by a Mammalian Receptor Repertoire» Science Signaling 2 (60): ra9–ra9. doi:10.1126/scisignal.2000016. ISSN 1945-0877. PMID 19261596. PMC PMC2774247. (Noiz kontsultatua: 2021-04-28).

[8] (Ingelesez) Block, Eric; Batista, Victor S.; Matsunami, Hiroaki; Zhuang, Hanyi; Ahmed, Lucky. (2017-05-10). «The role of metals in mammalian olfaction of low molecular weight organosulfur compounds» Natural Product Reports 34 (5): 529–557. doi:10.1039/C7NP00016B. ISSN 1460-4752. PMID 28471462. PMC PMC5542778. (Noiz kontsultatua: 2021-04-28).

[9] (Ingelesez) «Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2» Journal of Structural Biology 159 (3): 400–412. 2007-09-01 doi:10.1016/j.jsb.2007.04.013. ISSN 1047-8477. (Noiz kontsultatua: 2021-04-28).

[10] (Ingelesez) Audouze, Karine; Tromelin, Anne; Bon, Anne Marie Le; Belloir, Christine; Petersen, Rasmus Koefoed; Kristiansen, Karsten; Brunak, Søren; Taboureau, Olivier. (2014-04-02). «Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome» PLOS ONE 9 (4): e93037. doi:10.1371/journal.pone.0093037. ISSN 1932-6203. PMID 24695519. PMC PMC3973694. (Noiz kontsultatua: 2021-04-28).

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