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P. Eline Slagboom (b. January 18, 1960, Dordrecht) is a Dutch biologist specializing in the human familial longevity and ageing.

• High School: Christelijk Lyceum, Delft, 1978
• Bachelors: Leiden University in Biology, 1979
• Masters: Leiden University in Biology, 1985
• Ph.D.: Leiden University (thesis: Genomic Instability and Aging), 1993

After receiving her Ph.D. Slagboom joined the Department of Vascular and Connective Tissues Research at the Gaubius Laboratory, TNO-PG. As a post doc she initiated a unit for genetic epidemiological studies aimed at the identification of genetic determinants of multifactorial diseases. Slagboom started between 1995 and 1997 a genetic research line on osteoarthritis (OA) including linkage studies in families with early onset OA, genetic association studies in population cohorts and linkage studies in populations of affected sibling-pairs. From 1998 on, Slagboom, in collaboration with research groups at different universities, obtained various grants that allowed initiation of a genotyping facility for genome scanning at TNO. In 2000 Slagboom was appointed as professor of Molecular Epidemiology at the Leiden University Medical Center (LUMC). She established a new section of Molecular Epidemiology and Genotyping Center at the department of Medical Statistics and Bioinformatics. Slagboom has initiated a Masterclass for Statistical Analysis of Genetic Data and Bioinformatics in Genomic Research and is involved in various teaching activities.

Focus of the research in the past 10 years is on genomic, epigenetic and biomarker studies of healthy/unhealthy ageing and familial longevity in humans. These studies include genomics, metabolomics and proteomics analysis of age-related disease. A diversity of human cohorts with unique study designs is being analysed for this purpose. Slagboom is one of two founders of the Research on Ageing at LUMC supported among other foundations by Netherlands Genomic Initiative (NGI). She initiated and heads the Leiden Longevity Study (LLS) together with Prof. Dr. R.G.J. Westendorp MD and a research cohort of osteoarthritis patients (GARP: Genetics, Arthrosis and progression). Mission of her research group is the identification of genomic factors, biomarkers and functional mechanisms marking and contributing to complex diseases in humans with a focus on ageing, longevity and age-related disease. Slagboom has a leading role in large consortia within ageing research such as the Netherlands Consortium on Healthy Ageing (NCHA), in which she established collaborative research with industry, and EU large scale collaborative research project (Treat~OA, GEHA and LIFESPAN).

Currently she heads a group of 15-20 scientists and academic staff has now started to obtain grants for new research lines (functional genomic studies in osteoarthritis and studies into interaction between genetic and epigenetic variation). She is PI of a new large scale collaborative FP7-EU project (IDEAL: Integrated research on DEvelopmental determinants of Ageing and Longevity) together with Prof. Dr. Bas Zwaan (Wageningen University and Research Centre) from 2011 – 2016.

Leiden Longevity study

Slagboom has built a database of 420 families with long lived siblings (over 90 years of age) and family members in the Netherlands, which has been used for many of longevity studies. The siblings and their families have undergone periodic testing over a period of decades, providing a mass of longitudinal data for statistical analysis. A large number of participants have also provided blood, skin fibroblast, PBMCs and urine samples for testing of DNA, RNA and proteins. Her research has primarily focused on better understanding the influence of heredity on complex diseases, including cardiovascular diseases. This work is in collaboration with the Gerontology and Geriatics department of the LUMC.

GARP study (genetics, arthrosis and progression)

Slagboom has built a database of 200 sibling pair both affected with osteoarthitis and non affected partners in the Netherlands, which has been used for many osteoarthritis studies. The patients and their partners have undergone periodic testing over a period of decades, providing a mass of longitudinal data for statistical analysis. A large number of participants have also provided blood and urine samples for testing of DNA, RNA and proteins. Her research has primarily focused on better understanding the influence of heredity on complex diseases. This work is in collaboration with the Reumatology department of the LUMC.

• Dr Maarten Rozing completed his PhD ‘Endocrine and metabolic features of familial longevity The Leiden Longevity Study’ in 2011.
• Dr Rita Slof-Op ‘t Landt completed her PhD ‘Genetic Determinants of Eating Disorders’ in 2011.
• Dr Renee Ruhaak completed her PhD 'Glycomics based biomarkers of the rate of aging : development and applications of high-throughput N-glycan analysis' in 2011.
• Dr Steffan Bos completed his PhD 'Genes and mediators of inflammation and development in osteoarthritis' in 2010.
• Dr Maris Kuningas completed her PhD ‘A Study into Genes Encoding Longevity in Humans’ in 2007.
• Dr Josine Min completed her PhD ‘Generalised osteoarthritis: from mendelian disorder to complex disease’ in 2007.
• Dr Naghmeh Riyazi completed her PhD ‘Familial osteoarthritis. Risk factors and determinants of outcome’ in 2006.
• Dr Behrooz Alizadeh completed his PhD ’Osteoarthritis and hemochromatosis, a genetic epidemiological study’ in 2005.
• Dr Marian Beekman completed her PhD ‘Towards mapping QTLs influencing parameters of Lipid Metabolism in Human Twins’ in 2004.
• Dr Bas Heijmans completed his PhD ‘Common Gene Variants and Mortality in the Population at Large’ in 2000.
• Dr Casper Bijkerk completed his PhD ‘Genetic epidemiology of osteoarthritis’ in 1999.
• Dr Ingrid Meulenbelt completed her PhD ‘Genetic Predisposing Factors Of Osteoarthritis’ in 1997.

• Board member of BBMRI (Biobanking and Biomolecular Resources Research Infrastructure) - current
• Member of Editorial Board of Aging Cell – current
• Reviewer of NWO (Netherlands Organisation for Scientific Research) ALW Top grants – current
• Member of Committee Research ‘Decennium van het Bewegingsapparaat’
• Member of Committee Priorities in Genetic Research, Dutch Heart Foundation (NHS)
• Member of Editorial Board of Experimental Gerontology, Mechanisms of Ageing and Development and of Biogerontology
• Member of ZonMW VIDI committee
• Member of the Scientific committee, the “Wetenschappelijke Advies Commissie” (WAC) of the Dutch Heart Foundation (Nederlandse Hartstichting, NHS).

• The role of collagen genes in the aetiology of osteoarthritis (NWO 904-54-547).
• Genetic determinants of generalised osteoarthritis (Reumafonds 936).
• Mapping QTLs for cardiovascular disease (fine mapping) (Hartstichting 98.199).
• The role of a frequent variant of the MTHFR gene in disease and mortality (ZON 97-1-366).
• Testing candidate genes for osteoarthritis. Grant from Pfizer Central Research (Groton, 1998).
• Localisation of gene loci contributing to osteoarthritis (OA) (NWO programme 904-61-085).
• High Throughput analysis of SNPs for the study of major complex traits and diseases (NWO investeringssubsidie middelgroot 911-03-016).
• The genetic determination of longevity and disease at old age. Genetic subdivision of IOP Genomics (IGE01014). PI R.G.J. Westendorp.
• The role of cytokine genes in osteoarthritis (Reumafonds 2004).
• Biomarkers of the rate of ageing (IOP Genomics IGE05007B).
• Lipid and fatty acid metabolism: integrated analysis of genetic variation, biomarkers and environmental factors to identify new classifiers of incident MI risk and to maximize biological understanding (Nederlandse Hartstichting 2006B195).
• Identification of epigenetic risk factors for coronary heart disease: towards an integrated analysis of genetic and epigenetic variation in cardiovascular research (Nederlandse Hartstichting 2006B083). PI B.T. Heijmans.
• COMO Comprehensive Molecular Profiling (HST 2008). Collaboration with Technical University of Delft and University Leiden LIACS.
• NCHA Netherlands Consortium for Healthy Ageing (NGI 2008). Collaboration with ErasmusMC Rotterdam.
  

Co-applicant on additional grants.

• Localisation of QTL’s for cardiovascular disease (NIH: RO1 HL55976-01).
• The genetic basis of anxiety and depression: mapping QTL's (NWO programma 904-61-090).
• Genetics of individual differences in smoking initiation and persistence (NWO 985-10-002).
  

EU grant, PI.

• IDEAL Integrated research on Developmental determinants of Ageing and Longevity (FP7-HEALTH-2010-two stage).

EU grants, participating as board member/workpackage leader.

• Geha Genetic of Healthy Ageing.
• LifeSpan Integrated research into Development and Ageing (Network of Excellence).
• Linkage Coordination and Consolidation of European Biogerontology: en route towards formation of a European College of Biogerontology.
• Mark-Age European Study to Establish Biomarkers of Human Ageing.
• Treat-OA Translational Research in Europe – Applied Technologies for Osteoarthritis.

A complete list of publications of P.E. Slagboom.

Slagboom lives in Woubrugge. She is married to jazz musician Toon Roos and has a daughter and a son.

Category:1960 births Category:Living people Category:People from Dordrecht Category:Dutch Biologists Category:Leiden University alumni Category:Leiden University Medical Center faculty