Talk:Parabrachial nuclei

This article is rated Start-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects:

Anatomy: Neuroanatomy Mid‑importance This article is within the scope of WikiProject Anatomy, a collaborative effort to improve the coverage of Anatomy on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.AnatomyWikipedia:WikiProject AnatomyTemplate:WikiProject AnatomyAnatomy articles Mid This article has been rated as Mid-importance on the project's importance scale. This article has been classified as relating to neuroanatomy. Neuroscience Mid‑importance This article is within the scope of WikiProject Neuroscience, a collaborative effort to improve the coverage of Neuroscience on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.NeuroscienceWikipedia:WikiProject NeuroscienceTemplate:WikiProject Neuroscienceneuroscience articles Mid This article has been rated as Mid-importance on the project's importance scale.

The parabrachial nucleus seems to be a crucial part in the hunger-satiety circuit. From https://www.technologyreview.com/2024/01/02/1084713/how-does-hunger-work-appetite/

In 2014, Lowell used the remote-control tool to methodically turn each bundle of neurons leading out of the PVH on and off, to see which ones produced satiety. Once he identified the neurons that affected satiety, he followed them out of the hypothalamus. It led him to an area in the brain stem called the parabrachial nucleus (PBN)—the third key hub involved in the hunger-satiety circuit.

For the past eight years, Lowell and Andermann have been looking for the PBN neurons involved in hunger. It’s a painstaking hunt—the PBN contains hundreds of thousands of neurons. Lowell’s lab is tracing the hunger-satiety circuit forward out of the PBN while Andermann’s lab works backwards toward it from the insular cortex, an area associated with the conscious experience of bodily states like hunger.

The sheer number of neurons in the PBN makes the task daunting. It’s made even more complicated by the fact that the PBN isn’t just involved in sending hunger signals to higher-order brain processing centers but is also the final stop for scores of other impulses and needs. Agentjoerg (talk) 05:41, 28 July 2024 (UTC)[reply]