OR1A2

OR1A2
Identifiers
Aliases	OR1A2, OR17-6, olfactory receptor family 1 subfamily A member 2
External IDs	OMIM: 618047; MGI: 3030237; GeneCards: OR1A2; OMA:OR1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,198,448 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	74,089,438 bp
RNA expression pattern
	Top expressed in
	testicle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	positive regulation of cytokinesis; sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	26189
	404316
	ENSG00000172150
	ENSMUSG00000070378
	Q9Y585
	Q7TRX2
	NM_012352
	NM_207622
	NP_036484
	NP_997505
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.^[5]^[6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1.^[7] Examples of known ligands, most of which have citrus or fruity smells:^[7]^[8]

(S)-(−)-citronellal
Helional
Heptanal
Octanal
Nonanal (weaker than heptanal/octanal^[7])
Hydroxycitronellal
Citral
(S)-(−)-Citronellol (in contrast to OR1A1 only this enantiomer is effective; weaker than citronellal^[7])

Notes

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070378 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
^ ^a ^b "Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2".
^ ^a ^b ^c ^d Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.
^ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

OR1A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070378 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10673334-5] Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.

[entrez-6] "Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2".

[pmid17601748-7] Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.

[pmid24695519-8] Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

[1]

OR1A2

Ligands

See also

Notes

References

Further reading

External links