Cell adhesion molecule 1

CADM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BIN, 4H5S
Identifiers
Aliases	CADM1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1, cell adhesion molecule 1
External IDs	OMIM: 605686; MGI: 1889272; HomoloGene: 8641; GeneCards: CADM1; OMA:CADM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	115,504,957 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	47,858,115 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; pons; ; periodontal fiber; ; Achilles tendon; ; caput epididymis; ; corpus callosum; ; visceral pleura; ; islet of Langerhans; ; spinal ganglia; ; beta cell;
	Top expressed in
	epithelium of lens; ; otic placode; ; ciliary body; ; subiculum; ; otic vesicle; ; iris; ; CA3 field; ; saccule; ; neural layer of retina; ; amygdala;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein homodimerization activity; protein binding; signaling receptor binding; cell adhesion molecule binding;
Cellular component	integral component of membrane; membrane; cell-cell junction; synapse; integral component of plasma membrane; cell junction; basolateral plasma membrane; plasma membrane;
Biological process	cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; activated T cell proliferation; immune system process; multicellular organism development; cell adhesion; spermatogenesis; adherens junction organization; T cell mediated cytotoxicity; homophilic cell adhesion via plasma membrane adhesion molecules; apoptotic process; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity; detection of stimulus; cell recognition; viral process;
	Sources:Amigo / QuickGO
Orthologs
	23705
	54725
	ENSG00000182985
	ENSMUSG00000032076
	Q9BY67
	Q8R5M8
	NM_001098517; NM_001301043; NM_001301044; NM_001301045; NM_014333
	NM_001025600; NM_018770; NM_207675; NM_207676; NM_001310841
	NP_001091987; NP_001287972; NP_001287973; NP_001287974; NP_055148
	NP_001020771; NP_001297770; NP_061240; NP_997558; NP_997559
	Wikidata
View/Edit Human	View/Edit Mouse

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.^[5]^[6]

Interactions

Cell adhesion molecule 1 has been shown to interact with EPB41L3.^[7]

Association studies

Genome-wide association studies identified an association between body mass index and two loci near the CADM1 and CADM2 gene.^[8] Experimental results of another study showed that obese mice had an over expression of both CADM1 and CADM2 genes, and that loss of CADM1 protected mice from obesity, promoting a negative energy balance and weight loss.^[9] Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and CADM1.^[10] In the brain, this genes mediate synaptic assembly, and mutations in CADM1 are also associated with Autistic spectrum disorder. ^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182985 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032076 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics. 62 (2): 139–46. doi:10.1006/geno.1999.6001. PMID 10610705.
^ "Entrez Gene: CADM1 cell adhesion molecule 1".
^ Yageta, Mika; Kuramochi Masami; Masuda Mari; Fukami Takeshi; Fukuhara Hiroshi; Maruyama Tomoko; Shibuya Masabumi; Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. 62 (18): 5129–33. ISSN 0008-5472. PMID 12234973.
^ Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. (November 2010). "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index". Nature Genetics. 42 (11): 937–48. doi:10.1038/ng.686. PMC 3014648. PMID 20935630.
^ Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, et al. (August 2017). "Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1". Nature Neuroscience. 20 (8): 1096–1103. doi:10.1038/nn.4590. PMC 5533218. PMID 28628102.
^ Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JR, Gaspar HA, et al. (August 2019). "Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa". Nature Genetics. 51 (8): 1207–1214. doi:10.1038/s41588-019-0439-2. PMC 6779477. PMID 31308545.
^ Fujita E, Tanabe Y, Imhof BA, Momoi MY, Momoi T (December 2012). "A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum". J Neurochem. 123 (5): 886–94. doi:10.1111/jnc.12022. PMID 22994563.

Watabe K, Ito A, Koma YI, Kitamura Y (2004). "IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function". Histol. Histopathol. 18 (4): 1321–9. PMID 12973698.
Kuramochi M, Fukuhara H, Nobukuni T, et al. (2001). "TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer" (PDF). Nat. Genet. 27 (4): 427–30. doi:10.1038/86934. hdl:2241/1028. PMID 11279526. S2CID 9773234.
Masuda M, Yageta M, Fukuhara H, et al. (2002). "The tumor suppressor protein TSLC1 is involved in cell-cell adhesion". J. Biol. Chem. 277 (34): 31014–9. doi:10.1074/jbc.M203620200. PMID 12050160.
Fukuhara H, Kuramochi M, Fukami T, et al. (2003). "Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer". Jpn. J. Cancer Res. 93 (6): 605–9. doi:10.1111/j.1349-7006.2002.tb01297.x. PMC 5927049. PMID 12079507.
Allinen M, Peri L, Kujala S, et al. (2002). "Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation". Genes Chromosomes Cancer. 34 (4): 384–9. doi:10.1002/gcc.10079. PMID 12112527. S2CID 396701.
Biederer T, Sara Y, Mozhayeva M, et al. (2002). "SynCAM, a synaptic adhesion molecule that drives synapse assembly". Science. 297 (5586): 1525–31. Bibcode:2002Sci...297.1525B. doi:10.1126/science.1072356. PMID 12202822. S2CID 14529914.
Yageta M, Kuramochi M, Masuda M, et al. (2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. 62 (18): 5129–33. PMID 12234973.
Jansen M, Fukushima N, Rosty C, et al. (2003). "Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs". Cancer Biol. Ther. 1 (3): 293–6. doi:10.4161/cbt.84. PMID 12432281.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Honda T, Tamura G, Waki T, et al. (2003). "Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines". Jpn. J. Cancer Res. 93 (8): 857–60. doi:10.1111/j.1349-7006.2002.tb01329.x. PMC 5927103. PMID 12716461.
Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
Ito A, Okada M, Uchino K, et al. (2003). "Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma". Lab. Invest. 83 (8): 1175–83. doi:10.1097/01.LAB.0000081391.28136.80. PMID 12920246.
Fukami T, Fukuhara H, Kuramochi M, et al. (2003). "Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines". Int. J. Cancer. 107 (1): 53–9. doi:10.1002/ijc.11348. PMID 12925956. S2CID 26363429.
Uchino K, Ito A, Wakayama T, et al. (2003). "Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung". Cancer. 98 (5): 1002–7. doi:10.1002/cncr.11599. PMID 12942568. S2CID 35242800.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Fukuhara H, Masuda M, Yageta M, et al. (2003). "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg". Oncogene. 22 (40): 6160–5. doi:10.1038/sj.onc.1206744. PMID 13679854.
Ito T, Shimada Y, Hashimoto Y, et al. (2003). "Involvement of TSLC1 in progression of esophageal squamous cell carcinoma". Cancer Res. 63 (19): 6320–6. PMID 14559819.
Mao X, Seidlitz E, Ghosh K, et al. (2004). "The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer". Cancer Res. 63 (22): 7979–85. PMID 14633730.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182985 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032076 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610705-5] Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics. 62 (2): 139–46. doi:10.1006/geno.1999.6001. PMID 10610705.

[entrez-6] "Entrez Gene: CADM1 cell adhesion molecule 1".

[pmid12234973-7] Yageta, Mika; Kuramochi Masami; Masuda Mari; Fukami Takeshi; Fukuhara Hiroshi; Maruyama Tomoko; Shibuya Masabumi; Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. 62 (18): 5129–33. ISSN 0008-5472. PMID 12234973.

[Speliotes-8] Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, et al. (November 2010). "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index". Nature Genetics. 42 (11): 937–48. doi:10.1038/ng.686. PMC 3014648. PMID 20935630.

[Rethjen-9] Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, et al. (August 2017). "Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1". Nature Neuroscience. 20 (8): 1096–1103. doi:10.1038/nn.4590. PMC 5533218. PMID 28628102.

[WatsonYilmaz2019-10] Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JR, Gaspar HA, et al. (August 2019). "Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa". Nature Genetics. 51 (8): 1207–1214. doi:10.1038/s41588-019-0439-2. PMC 6779477. PMID 31308545.

[Fujita-11] Fujita E, Tanabe Y, Imhof BA, Momoi MY, Momoi T (December 2012). "A complex of synaptic adhesion molecule CADM1, a molecule related to autism spectrum disorder, with MUPP1 in the cerebellum". J Neurochem. 123 (5): 886–94. doi:10.1111/jnc.12022. PMID 22994563.

[1]

Cell adhesion molecule 1

Interactions

Association studies

See also

References

Further reading