ARHGAP27

ARHGAP27
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PP2
Identifiers
Aliases	ARHGAP27, CAMGAP1, PP905, SH3D20, SH3P20, Rho GTPase activating protein 27
External IDs	OMIM: 610591; MGI: 1916903; HomoloGene: 45715; GeneCards: ARHGAP27; OMA:ARHGAP27 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	45,434,421 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,254,518 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; mucosa of transverse colon; ; spleen; ; duodenum; ; appendix; ; minor salivary glands; ; vagina; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; pyloric antrum; ; otic vesicle; ; esophagus; ; right kidney; ; gastric mucosa; ; yolk sac; ; epithelium of stomach; ; lip; ; fibula;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; GTPase activator activity;
Cellular component	intracellular anatomical structure; membrane; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	endocytosis; signal transduction; positive regulation of GTPase activity; receptor-mediated endocytosis; regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	201176
	544817
	ENSG00000159314; ENSG00000276836; ENSG00000276907
	ENSMUSG00000034255
	Q6ZUM4; Q8N2Y9
	A2AB59
	NM_001159330; NM_001282290; NM_174919; NM_199282
	NM_001205236; NM_133715; NM_183288
	NP_001269219; NP_777579; NP_954976; NP_954976.1
	NP_001192165; NP_598476; NP_899111
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. ^[5]

Function

This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].

References

^ ^a ^b ^c ENSG00000276836, ENSG00000276907 GRCh38: Ensembl release 89: ENSG00000159314, ENSG00000276836, ENSG00000276907 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Rho GTPase activating protein 27". Retrieved 2018-05-30.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Rho GTPase-activating protein 27 (ARHGAP27)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000276836, ENSG00000276907 GRCh38: Ensembl release 89: ENSG00000159314, ENSG00000276836, ENSG00000276907 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034255 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Rho GTPase activating protein 27". Retrieved 2018-05-30.

[1]