Festuclavine dehydrogenase

Festuclavine dehydrogenase (EC 1.5.1.44, FgaFS, festuclavine synthase) is an enzyme with systematic name festuclavine:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

Festuclavine dehydrogenase
Identifiers
EC no.1.5.1.44
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
festuclavine + NAD+ 6,8-dimethyl-6,7-didehydroergoline + NADH + H+

The enzyme takes part in the biosynthesis of fumigaclavine C.

References

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  1. ^ Wallwey C, Matuschek M, Xie XL, Li SM (August 2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3". Organic & Biomolecular Chemistry. 8 (15): 3500–8. doi:10.1039/c003823g. PMID 20526482.
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