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extended-abstract

Deep Learning in Medical Imaging: fMRI Big Data Analysis via Convolutional Neural Networks

Published: 22 July 2018 Publication History

Abstract

This paper aims at implementing novel biomarkers extracted from functional magnetic resonance imaging (fMRI) images taken at resting-state using convolutional neural networks (CNN) to predict relapse in heavy smoker subjects. In this regard, two classes of subjects were studied. The first class contains 19 subjects that took the drug N-acetylcysteine (NAC), and the second class contains 20 subjects that took a placebo. The subjects underwent a double-blind smoking cessation treatment. The resting-state fMRI of the subjects' brains were recorded through 200 snapshots before and after the treatment. The relapse data was assessed after 6 months past the treatment. The data was pre-processed and an undercomplete autoencoder along with various similarity metrics was developed to extract salient features that could differentiate the pre and post treatment images. Finally, the extracted feature matrix was fed into robust classification algorithms to classify the subjects in terms of relapse and non-relapse. The XGBoost algorithm with 0.86 precision and an AUC of 0.92 outperformed the other classification methods in prediction of relapse in subjects.

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cover image ACM Other conferences
PEARC '18: Proceedings of the Practice and Experience on Advanced Research Computing: Seamless Creativity
July 2018
652 pages
ISBN:9781450364461
DOI:10.1145/3219104
Permission to make digital or hard copies of part or all of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for third-party components of this work must be honored. For all other uses, contact the Owner/Author.

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 22 July 2018

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Author Tags

  1. Autoencoder
  2. Big Data
  3. Convolutional Neural Network
  4. Deep Learning
  5. fMRI

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  • Extended-abstract
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  • Refereed limited

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PEARC '18

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PEARC '18 Paper Acceptance Rate 79 of 123 submissions, 64%;
Overall Acceptance Rate 133 of 202 submissions, 66%

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