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Semantic systems biology: enabling integrative biology via semantic web technologies

Published: 25 May 2011 Publication History

Abstract

The vast amounts of knowledge in the biomedical domain have paved the way for a new paradigm in biological research called Systems Biology, essentially an approach that relies on the integration of all available knowledge of a biological system in a single model. This approach promotes a comprehensive understanding of biological systems, driven by data integration and mathematical modelling. However, the sheer volume, variation and complexity of the current biological data pose a number of hurdles in knowledge management that need to be overcome. The Semantic Web offers various solutions to these challenges. With our initiative, named Semantic Systems Biology (SSB), we augment the systems biology approach with semantic web technologies to enable smooth data integration, rigorous knowledge representation, efficient querying, and hypothesis generation. Here we present an overview of the projects associated with the SSB initiative. Access to our resources developed within the SSB frame is provided on our website: http://www.semantic-systems-biology.org.

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  1. Semantic systems biology: enabling integrative biology via semantic web technologies

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      cover image ACM Other conferences
      WIMS '11: Proceedings of the International Conference on Web Intelligence, Mining and Semantics
      May 2011
      563 pages
      ISBN:9781450301480
      DOI:10.1145/1988688
      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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      Published: 25 May 2011

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      Author Tags

      1. OWL
      2. RDF
      3. SPARQL
      4. bio-ontologies
      5. semantic web technology
      6. semantics
      7. systems biology

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