Modelling and mathematical studies of neuronal NO‐synthase: NO versus NA theory
Abstract
Purpose
The purpose of this paper is to present modelling and mathematical studies of neuronal NO‐synthase and discuss the case for nitric oxide (NO) versus nitroso‐arginine (NA) theory.
Design/methodology/approach
Introduces recent studies, NO studied models and the experimental model before considering the diffusion‐reaction model. Enzymatic kinetics and an analysis of systems and the NA diffusion equations in mice cortex are given. Numerical results are featured.
Findings
Based on these studies, both a bio‐mathematical and physiological conclusions are given. The way to protect the brain was to inhibit the NO‐synthase of the neurons during a stroke.
Originality/value
The paper is of value, particularly as stroke is the second leading cause of mortality worldwide and the most common cause of dementia in western countries. In Europe, each year, over 1,200,000 people experience a stroke.
Keywords
Citation
Guellal, S., Meulemans, A. and Khelifa, S. (2009), "Modelling and mathematical studies of neuronal NO‐synthase: NO versus NA theory", Kybernetes, Vol. 38 No. 5, pp. 725-732. https://doi.org/10.1108/03684920910962623
Publisher
:Emerald Group Publishing Limited
Copyright © 2009, Emerald Group Publishing Limited