DOT1L

DOT1L
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NW3, 2MV7, 3QOW, 3QOX, 3SR4, 3SX0, 3UWP, 4EK9, 4EKG, 4EKI, 4EQZ, 4ER0, 4ER3, 4ER5, 4ER6, 4ER7, 4HRA, 4WVL, 5DSX, 5JUW, 5DRT, 5DTM, 5DTQ, 5DT2, 5DRY, 5DTR
Dynodwyr
Cyfenwau	DOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase
Dynodwyr allanol	OMIM: 607375 HomoloGene: 32779 GeneCards: DOT1L
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • DNA binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • histone methyltransferase activity • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H3-K79 specific) Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • telomere • intracellular membrane-bounded organelle • GO:0009327 protein-containing complex Prosesau biolegol • telomere organization • methylation • regulation of transcription regulatory region DNA binding • regulation of receptor signaling pathway via JAK-STAT • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell population proliferation • histone H3-K79 methylation • DNA damage checkpoint signaling • GO:0100026 DNA repair • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • regulation of cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84444	n/a
Ensembl	ENSG00000104885	n/a
UniProt	Q8TEK3	n/a
RefSeq (mRNA)	NM_032482	n/a
RefSeq (protein)	NP_115871	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DOT1L yw DOT1L a elwir hefyd yn Histone-lysine N-methyltransferase, H3 lysine-79-specific a Histone-lysine N-methyltransferase, H3 lysine-79 specific (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DOT1L.

• DOT1
• KMT4

• "Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. ". J Control Release. 2015. PMID 26385168.
• "Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential. ". Cell Rep. 2015. PMID 25921540.
• "MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. ". Cell Rep. 2017. PMID 28076791.
• "Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays. ". J Chem Inf Model. 2016. PMID 26914852.
• "Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.". Nat Commun. 2016. PMID 26830124.