DENND1A

DENND1A
Identifikatori
Aliasi	DENND1A
Vanjski ID-jevi	OMIM: 613633 MGI: 2442794 HomoloGene: 17141 GeneCards: DENND1A
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	123,930,152 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	38,177,402 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• guanyl-nucleotide exchange factor activity; • SH3 domain binding; • lipid binding; • phosphatidylinositol phosphate binding; • phosphatidylinositol-3-phosphate binding;
Ćelijska komponenta	• membrana; • ćelijska membrana; • sinapsa; • međućelijske veze; • soma; • dendrit; • clathrin-coated vesicle membrane; • presynaptic membrane; • GO:0016023 citoplazmatska vezikula; • clathrin-coated vesicle; • nukleoplazma; • citosol; • intracellular membrane-bounded organelle;
Biološki proces	• Endocitoza; • regulation of Rab protein signal transduction; • synaptic vesicle endocytosis; • protein transport; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • endocytic recycling;
	Izvori:Amigo / QuickGO
Ortolozi
	57706
	227801
	ENSG00000119522
	ENSMUSG00000035392
	Q8TEH3
	Q8K382
NM_020946; NM_024820; NM_001352964; NM_001352965; NM_001352966;
	NM_001352967; NM_001352968; NM_001393654; NM_001400446; NM_001400449
	NM_146122; NM_001362973; NM_001362977; NM_001362978
NP_065997; NP_079096; NP_001339893; NP_001339894; NP_001339895;
	NP_001339896; NP_001339897
	NP_666234; NP_001349902; NP_001349906; NP_001349907
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1A sa DENN-domenom jest protein koji je kod ljudi kodiran genom DENND1A.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.109 aminokiselina, а molekulska težina 110.577 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGSRIKQNPE	TTFEVYVEVA	YPRTGGTLSD	PEVQRQFPED	YSDQEVLQTL
TKFCFPFYVD	SLTVSQVGQN	FTFVLTDIDS	KQRFGFCRLS	SGAKSCFCIL
SYLPWFEVFY	KLLNILADYT	TKRQENQWNE	LLETLHKLPI	PDPGVSVHLS
VHSYFTVPDT	RELPSIPENR	NLTEYFVAVD	VNNMLHLYAS	MLYERRILII
CSKLSTLTAC	IHGSAAMLYP	MYWQHVYIPV	LPPHLLDYCC	APMPYLIGIH
LSLMEKVRNM	ALDDVVILNV	DTNTLETPFD	DLQSLPNDVI	SSLKNRLKKV
STTTGDGVAR	AFLKAQAAFF	GSYRNALKIE	PEEPITFCEE	AFVSHYRSGA
MRQFLQNATQ	LQLFKQFIDG	RLDLLNSGEG	FSDVFEEEIN	MGEYAGSDKL
YHQWLSTVRK	GSGAILNTVK	TKANPAMKTV	YKFAKDHAKM	GIKEVKNRLK
QKDIAENGCA	PTPEEQLPKT	APSPLVEAKD	PKLREDRRPI	TVHFGQVRPP
RPHVVKRPKS	NIAVEGRRTS	VPSPEQPQPY	RTLRESDSAE	GDEAESPEQQ
VRKSTGPVPA	PPDRAASIDL	LEDVFSNLDM	EAALQPLGQA	KSLEDLRAPK
DLREQPGTFD	YQRLDLGGSE	RSRGVTVALK	LTHPYNKLWS	LGQDDMAIPS
KPPAASPEKP	SALLGNSLAL	PRRPQNRDSI	LNPSDKEEVP	TPTLGSITIP
RPQGRKTPEL	GIVPPPPIPR	PAKLQAAGAA	LGDVSERLQT	DRDRRAALSP
GLLPGVVPQG	PTELLQPLSP	GPGAAGTSSD	ALLALLDPLS	TAWSGSTLPS
RPATPNVATP	FTPQFSFPPA	GTPTPFPQPP	LNPFVPSMPA	APPTLPLVST
PAGPFGAPPA	SLGPAFASGL	LLSSAGFCAP	HRSQPNLSAL	SMPNLFGQMP
MGTHTSPLQP	LGPPAVAPSR	IRTLPLARSS	ARAAETKQGL	ALRPGDPPLL
PPRPPQGLEP	TLQPSAPQQA	RDPFEDLLQK	TKQDVSPSPA	LAPAPDSVEQ
LRKQWETFE

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119522 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035392 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
^ "Entrez Gene: DENND1A DENN/MADD domain containing 1A".
^ "UniProt, Q8TEH3". Pristupljeno 7. 9. 2021.

Dopunska literatura

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119522 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035392 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10997877-5] Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

[entrez-6] "Entrez Gene: DENND1A DENN/MADD domain containing 1A".

[UniProt-7] "UniProt, Q8TEH3". Pristupljeno 7. 9. 2021.

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