S Wikipedije, slobodne enciklopedije
Beta-defenzin 127 je protein koji je kod ljudi kodiran genom DEFB127 .[ 3] [ 4]
Defenzini su cisteinskim kationima bogati polipeptidi koji su važni u imunskom odgovoru na napadajuće mikroorganizme . Protein kodiran ovim genom luči se kao član porodice beta-defenzinskih proteina. Beta-defenzinski geni nalaze se u nekoliko klastera u čitavom genomu, s tim da se ovaj gen transkribira u klasteru 20p13.[ 4]
^ a b c GRCh38: Ensembl release 89: ENSG00000088782 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy" . Proc Natl Acad Sci U S A . 99 (4): 2129–33. doi :10.1073/pnas.042692699 . PMC 122330 PMID 11854508 . ^ a b "Entrez Gene: DEFB127 defensin, beta 127" .
van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS (2000). "Defensins: key players or bystanders in infection, injury, and repair in the lung?". J. Allergy Clin. Immunol . 104 (6): 1131–8. doi :10.1016/S0091-6749(99)70004-7 . PMID 10588992 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics . 81 (2): 175–83. doi :10.1016/S0888-7543(02)00034-4 . PMID 12620395 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. doi :10.1038/414865a PMID 11780052 .
