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Autophosphorylation is a type of post-translational modification of proteins. It is generally defined as the phosphorylation of the kinase by itself. In eukaryotes, this process occurs by the addition of a phosphate group to serine, threonine or tyrosine residues within protein kinases, normally to regulate the catalytic activity. Autophosphorylation may occur when a kinases' own active site catalyzes the phosphorylation reaction (cis autophosphorylation), or when another kinase of the same type provides the active site that carries out the chemistry (trans autophosphorylation). The latter often occurs when kinase molecules dimerize. In general, the phosphate groups introduced are gamma phosphates from nucleoside triphosphates, most commonly ATP.

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  • Autophosphorylation is a type of post-translational modification of proteins. It is generally defined as the phosphorylation of the kinase by itself. In eukaryotes, this process occurs by the addition of a phosphate group to serine, threonine or tyrosine residues within protein kinases, normally to regulate the catalytic activity. Autophosphorylation may occur when a kinases' own active site catalyzes the phosphorylation reaction (cis autophosphorylation), or when another kinase of the same type provides the active site that carries out the chemistry (trans autophosphorylation). The latter often occurs when kinase molecules dimerize. In general, the phosphate groups introduced are gamma phosphates from nucleoside triphosphates, most commonly ATP. (en)
  • Con autofosforilazione si intende il processo attraverso cui una proteina, di solito un recettore di membrana, catalizza la propria fosforilazione a livello di specifici residui di serina, treonina o tirosina; in seguito all'interazione con un agonista (ormone, fattore di crescita, ecc.). (it)
  • 自己リン酸化(じこリンさんか、英: autophosphorylation)は、タンパク質の翻訳後修飾の1つである。一般的には、プロテインキナーゼによるキナーゼ自身のリン酸化として定義される。真核生物では、この過程はプロテインキナーゼ内のセリン、スレオニンまたはチロシン残基へのリン酸基の付加によって行われ、通常は触媒活性を調節するものである。自己リン酸化はキナーゼ自身の活性部位がリン酸化反応を触媒する場合(シス自己リン酸化)と、同種の他のキナーゼが活性部位を提供して反応が行われる場合(トランス自己リン酸化)がある。後者は多くの場合、キナーゼ分子が二量体化した時に行われる。一般的に、キナーゼに導入されるリン酸基はヌクレオシド三リン酸のγ-リン酸基であり、最も多いのはATP由来のものである。 (ja)
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  • Autophosphorylation is a type of post-translational modification of proteins. It is generally defined as the phosphorylation of the kinase by itself. In eukaryotes, this process occurs by the addition of a phosphate group to serine, threonine or tyrosine residues within protein kinases, normally to regulate the catalytic activity. Autophosphorylation may occur when a kinases' own active site catalyzes the phosphorylation reaction (cis autophosphorylation), or when another kinase of the same type provides the active site that carries out the chemistry (trans autophosphorylation). The latter often occurs when kinase molecules dimerize. In general, the phosphate groups introduced are gamma phosphates from nucleoside triphosphates, most commonly ATP. (en)
  • Con autofosforilazione si intende il processo attraverso cui una proteina, di solito un recettore di membrana, catalizza la propria fosforilazione a livello di specifici residui di serina, treonina o tirosina; in seguito all'interazione con un agonista (ormone, fattore di crescita, ecc.). (it)
  • 自己リン酸化(じこリンさんか、英: autophosphorylation)は、タンパク質の翻訳後修飾の1つである。一般的には、プロテインキナーゼによるキナーゼ自身のリン酸化として定義される。真核生物では、この過程はプロテインキナーゼ内のセリン、スレオニンまたはチロシン残基へのリン酸基の付加によって行われ、通常は触媒活性を調節するものである。自己リン酸化はキナーゼ自身の活性部位がリン酸化反応を触媒する場合(シス自己リン酸化)と、同種の他のキナーゼが活性部位を提供して反応が行われる場合(トランス自己リン酸化)がある。後者は多くの場合、キナーゼ分子が二量体化した時に行われる。一般的に、キナーゼに導入されるリン酸基はヌクレオシド三リン酸のγ-リン酸基であり、最も多いのはATP由来のものである。 (ja)
rdfs:label
  • Autophosphorylation (en)
  • Autofosforilazione (it)
  • 自己リン酸化 (ja)
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