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A metaheuristic approach to parameter estimation of a flexible parametric mixture cure rate model with interval-censored data. (English) Zbl 1538.62331

Summary: A flexible parametric mixture cure model, called bi-lognormal cure rate model or simply BLN model, is defined and studied. The BLN model can be effectively used to analyze survival dataset in the presence of long-term survivors, especially when the dataset presents the underlying phenomenon of latent competing risks or when there is evidence that a bimodal hazard function is appropriated to described it, which are advantages over other cure rate models found in the literature. We discuss the maximum likelihood estimation for the model parameters considering interval-censored data through the differential evolution algorithm that is a nature-inspired computing metaheuristic used for global optimization of functions defined in multidimensional spaces. This approach is also used because the likelihood function of the model is multimodal and the direct application of gradient methods in this case is not ideal, since such methods are local search methods with a high chance of getting stuck at a local maximum when the starting point is chosen outside the basin of attraction of a global maximum. In addition, a simulation study was implemented to compare the performance of differential evolution algorithm with the performance of the Newton-Raphson algorithm in terms of bias, root mean square error, and the coverage probability of the asymptotic confidence intervals for the parameters. Finally, an application of the BLN model to real data is presented to illustrate that it can provide a better fit than other mixture cure rate models.

MSC:

62P10 Applications of statistics to biology and medical sciences; meta analysis
62N01 Censored data models
62G05 Nonparametric estimation
62N05 Reliability and life testing

Software:

DEoptim; R; CRAN; gte

References:

[1] D. Ardia, K. Boudt, P. Carl, K. Mullen & B. Peterson. Differential evolution with DEoptim. The R Journal, 3 (2011), 27-34.
[2] N. Balakrishnan & W. Chen. “Lognormal Distributions and Properties. In: Handbook of Tables for Order Statistics from Lognormal Distributions with Applications”. Boston, Springer (1999). · Zbl 0917.62094
[3] J. Balka, A.F. Desmond & P.D. McNicholas. Review and implementation of cure models based on first hitting times for wiener processes. Lifetime Data Analysis, 15 (2009), 147-176. · Zbl 1282.62228
[4] S. Basu, A. Basu & C. Mukhopadhyay. Bayesian analysis for masked system failure data using non-identical Weibull models. Statistics and Probability Letters, 78 (1999), 255-275. · Zbl 1057.62532
[5] J. Berger & D. Sun. Bayesian analysis for the poly-Weibull distribution. Journal of the American Statistical Association, 88 (1993), 1412-1418. · Zbl 0792.62020
[6] J. Berkson & R. Gage. Survival curve for cancer patients following treatment. Journal of the American Statistical Association, 42 (1952), 501-515.
[7] J. Boag. Maximum likelihood estimates of the proportion of patients cured by cancer therapy. Journal of the Royal Statistical Society B, 11 (1949), 15-53. · Zbl 0034.08001
[8] P. Borges. EM algorithm-based likelihood estimation for a generalized Gompertz regression model in presence of survival data with long-term survivors: an application to uterine cervical cancer data. Journal of Statistical Computation and Simulation, 87 (2017), 1-11. · Zbl 07192025
[9] P. Borges, J. Rodrigues & N. Balakrishnan. Correlated destructive generalized power series cure rate models and associated inference with an application to a cutaneous melanoma data. Computational Statistics and Data Analysis, 56 (2012), 1703-1713. · Zbl 1465.62007
[10] P. Borges, J. Rodrigues, F. Louzada-Neto & N. Balakrishnan. A cure rate survival model under a hybrid latent activation scheme. Statistical Methods in Medical Research, 25 (2016), 838-856.
[11] V. Calsavara, A. Rodrigues, R. Rocha, V. Tomazella & F. Louzada-Neto. Defective regression models for cure rate modeling with interval-censored data. Biometrical Journal, 61 (2019), 841-859. · Zbl 1429.62503
[12] V. Chan & W. Meeker. A failure-time model for infant mortality and wearout failure models. IEEE Transactions on Reliability, 48 (1999), 377-387.
[13] M. Chen, J. Ibrahim & D. Sinha. A new Bayesian model for survival data with a surviving fraction. Journal of the American Statistical Association, 94 (1999), 909-914. · Zbl 0996.62019
[14] F. Cooner, S. Banerjee, B. Carlin & D. Sinha. Flexible cure rate modelling under latent activation schemes. Journal of the American Statistical Association, 102 (2007), 560-572. · Zbl 1172.62331
[15] D. Cox & D. Hinkley. “Theoretical Statistics”. London, Chapman and Hall (1974). · Zbl 0334.62003
[16] D. Cox & D. Oakes. “Analysis of Survival Data”. London, Chapman and Hall (1984).
[17] S. Das & P. Suganthan. Differential evolution: a survey of the state-of-the-art. IEEE Transactions on Evolutionary Computation, 3 (2011), 4-31.
[18] M. Dehghan & T. Duchesne. A generalization of turnbull’s estimator for nonparametric estimation of the conditional survival function with interval-censored data. Lifetime Data Analysis, 17 (2011), 234-255. · Zbl 1322.62267
[19] M. Dehghan, T. Duchesne & S. Baillargeon. “Package gte: Generalized Turnbull”s Estimator” (2015). URL http://CRAN.R-project.org/package=gte. R package version 1.2.2, R CRAN package repository.
[20] N. Demiris, D. Lunn & L. Sharples. Survival extrapolation using the poly-Weibull model. Statistical Methods in Medical Research, 24 (2015), 287-301.
[21] S. Elsayed, R. Sarker & D. Essam. A self-adaptive combined strategies algorithm for constrained optimization using differential evolution. Applied Mathematics and Computation, 241 (2014), 267-282. · Zbl 1334.90163
[22] J. Fachini, E. Ortega & F. Louzada-Neto. Influence diagnostics for polyhazard models in the presence of covariates. Statistical Methods and Applications, 17 (2008), 413-433. · Zbl 1405.62132
[23] V. Farewell. A model for a binary variable with time censored observations. Biometrics, 64 (1977), 43-46. · Zbl 0348.62048
[24] Trends Comput. Appl. Math., 24, N. 3 (2023)
[25] P. BORGES and M. CAMPOS 553
[26] V. Farewell. The use mixture models for the analysis of survival data with long term survivors. Biometrics, 38 (1982), 1041-1046.
[27] E. Hashimoto, E. Ortega & G. Cordeiro. A new long-term survival model with interval-censored data. Sankhya, 77 (2015), 207-239. · Zbl 1329.62395
[28] J. Kalbeisch & R. Prentice. “The Statistical Analysis of Failure Time Data”. New York, Wiley (1980). · Zbl 0504.62096
[29] T. Koutny. Using meta-differential evolution to enhance a calculation of a continuous blood glucose level. Computer Methods and Programs in Biomedicine, 133 (2016), 45-54.
[30] L. Kuo & T. Yang. Bayesian reliability modeling for masked system lifetime. Statistics and Probability Letters, 47 (2000), 229-241. · Zbl 0968.62072
[31] E. Lee & J. Wang. “Statistical Methods for Survival Data Analysis, 3rd ed.”. New Jersey, John Wiley and Sons (2003). · Zbl 1026.62103
[32] F. Lobato, V. Machado & V. Steffen Jr. Determination of an optimal control strategy for drug ad-ministration in tumor treatment using multi-objective optimization differential evolution. Computer Methods and Programs in Biomedicine, 131 (2016), 51-61.
[33] F. Louzada-Neto. Polyhazard regression models for lifetime data. Biometrics, 55 (1999), 1281-1285. · Zbl 1059.62597
[34] F. Louzada-Neto, C. Andrade & F. Almeida. On the non-identifiability problem arising on the poly-Weibull model. Communications in Statistics -Simulation and Computation, 33 (2004), 541-552. · Zbl 1100.62612
[35] R. Maller & X. Zhou. Testing for the presence of immune or cured individuals in censored survival data. Biometrics, 51 (1995), 1197-1205. · Zbl 0875.62516
[36] J. Mazucheli, F. Louzada-Neto & J. Achcar. Bayesian inference for polyhazard models in the presence of covariates. Computational Statistics and Data Analysis, 38 (2001), 1-14. · Zbl 1072.62540
[37] J. Mazucheli, F. Louzada-Neto & J. Achcar. The polysurvival model with long-term survivors. Brazilian Journal of Probability and Statistics, 26 (2012), 313-324. · Zbl 1238.62121
[38] H. Orkcu, E. Aksoy & M. Dogan. Estimating the parameters of 3-p Weibull distribution through differential evolution. Applied Mathematics and Computation, 251 (2015), 211-224. · Zbl 1328.62078
[39] S. Pal & N. Balakrishnan. Likelihood inference for COM-Poisson cure rate model with interval-censored data and Weibull lifetimes. Statistical Methods in Medical Research, 26 (2017), 2093-2113.
[40] K. Price, R. Storn & J. Lampinen. “Differential Evolution: A Practical Approach to Global Optimization, 2nd ed.”. Berlin, Springer-Verlag (2006).
[41] R Core Team. “R: A Language and Environment for Statistical Computing”. R Foundation for Statistical Computing, Vienna, Austria (2022). URL http://www.R-project.org/.
[42] R. Rocha, S. Nadarajah, V. Tomazella & F. Louzada-Neto. A new class of defective models based on the Marshall-Olkin family of distributions for cure rate modeling. Computational Statistics and Data Analysis, 107 (2017), 48-63. · Zbl 1466.62184
[43] J. Rodrigues, V. Cancho, M. Castro & F. Louzada-Neto. On the unification of the long-term survival models. Statistics and Probability Letters, 79 (2009), 753-759. · Zbl 1349.62485
[44] M. Roman, F. Louzada-Neto, V. Cancho & J. Leite. A new long-term survival distribution for cancer data. Journal of Data Science, 10 (2012), 241-258.
[45] S. Scolas, A. EL Ghouch, C. Lengrand & A. Oulhaj. Variable selection in a flexible parametric mixture cure model with interval-censored data. Statistics in Medicine, 35 (2016), 1210-1225.
[46] R. Storn & K. Price. Differential evolution -a simple and efficient heuristic for global optimization over continuous spaces. Journal of Global Optimization, 11 (1997), 341-359. · Zbl 0888.90135
[47] J. Sun. “The Statistical Analysis of Interval-Censored Failure Time Data”. New York, Chapman and Hall (2006). · Zbl 1127.62090
[48] R. Tsai & L. Hotta. Polyhazard models with dependent causes. Brazilian Journal of Probability and Statistics, 27 (2013), 357-376. · Zbl 1298.62109
[49] R. Tsai & L. Hotta. Polyhazard models with dependent causes, Fitting distributions with the poly-hazard model with dependence. Communications in Statistics -Theory and Methods, 44 (2015), 1886-1895. · Zbl 1320.62212
[50] A. Yakovlev & A. Tsodikov. “Stochastic Models of Tumor Latency and Their Biostatistical Applications”. Singapore: World Scientific Publishers (1996). · Zbl 0919.92024
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