Summary: Traditional Multidisciplinary Design Optimization (MDO) generates deterministic optimal designs, which are frequently pushed to the limits of design constraint boundaries, leaving little or no room to accommodate uncertainties in system input, modeling, and simulation. As a result, the design solution obtained may be highly sensitive to the variations of system input which will lead to performance loss and the solution is often risky (high likelihood of undesired events). Reliability-based design is one of the alternative techniques for design under uncertainty. The natural method to perform reliability analysis in multidisciplinary systems is the all-in-one approach where the existing reliability analysis techniques are applied directly to the system-level multidisciplinary analysis. However, the all-in-one reliability analysis method requires a double loop procedure and therefore is generally very time consuming. To improve the efficiency of reliability analysis under the MDO framework, a collaborative reliability analysis method is proposed in this paper. The procedure of the traditional Most Probable Point (MPP) based reliability analysis method is combined with the collaborative disciplinary analyses to automatically satisfy the interdisciplinary consistency when conducting reliability analysis. As a result, only a single loop procedure is required and all the computations are conducted concurrently at the individual discipline-level. Compared with the existing reliability analysis methods in MDO, the proposed method is efficient and therefore provides a cheaper tool to evaluate design feasibility in MDO under uncertainty. Two examples are used for the purpose of verification.